H2-Aa - histocompatibility 2, class II antigen A, alpha Gene

Also Known as Ia1; H2Aa; Ia-1; H-2Aa; Aalpha; IAalpha; I-Aalpha

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14960

Summary

Enables peptide antigen binding activity. Involved in response to interferon-gamma. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II and positive regulation of T cell differentiation. Located in external side of plasma membrane and lysosome. Part of MHC class II protein complex. Is expressed in central nervous system; retina; and thymus primordium. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); gastrointestinal system Cancer (multiple); glomerulonephritis (multiple); hematologic Cancer (multiple); and systemic scleroderma (multiple). Orthologous to several human genes including HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1). [provided by Alliance of Genome Resources, Apr 2022]

H2-Aa Products (2)

mRNA Protein Name
NM_010378.3 NP_034508.2 histocompatibility 2, class II antigen A, alpha precursor
NM_010378.3 NP_034508.2 histocompatibility 2, class II antigen A, alpha precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables peptide antigen binding IDA
IDA: Inferred from direct assay
9432982 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7985028 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within antigen processing and presentation IDA
IDA: Inferred from direct assay
9432982 MGI
acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
IDA: Inferred from direct assay
7679955 MGI
acts upstream of or within antigen processing and presentation of peptide antigen IDA
IDA: Inferred from direct assay
11069069 MGI
acts upstream of or within positive regulation of T cell differentiation IDA
IDA: Inferred from direct assay
8598041 MGI
Cellular Component GO Annotation Evidence References Source
part of MHC class II protein complex IDA
IDA: Inferred from direct assay
7679955 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
7679955 MGI
located in lysosome IDA
IDA: Inferred from direct assay
11854359 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
11854359 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histocompatibility 2, class II antigen A, alpha

  • H-2 class II histocompatibility antigen, A-B alpha chain

  • H-2 class II histocompatibility antigen, A-F alpha chain

  • H-2 class II histocompatibility antigen, A-K alpha chain

  • H-2 class II histocompatibility antigen, A-Q alpha chain

  • H-2 class II histocompa