H2-Ab1 - histocompatibility 2, class II antigen A, beta 1 Gene

Also Known as IAb; Ia2; Ia-2; Abeta; H-2Ab; H2-Ab; Rmcs1; I-Abeta

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14961

Summary

Enables several functions, including peptide antigen binding activity; protein antigen binding activity; and toxic substance binding activity. Involved in several processes, including B cell affinity maturation; cellular response to interferon-gamma; and positive regulation of T-helper 1 type immune response. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II and immune response. Located in Golgi apparatus; endosome; and external side of plasma membrane. Is integral component of membrane. Part of MHC class II protein complex. Is expressed in lung; metanephros; and thymus primordium. Orthologous to human HLA-DQB2 (major histocompatibility complex, class II, DQ beta 2). [provided by Alliance of Genome Resources, Apr 2022]

H2-Ab1 Products (1)

mRNA Protein Name
NM_207105.3 NP_996988.2 histocompatibility 2, class II antigen A, beta 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables peptide antigen binding IDA
IDA: Inferred from direct assay
9432982 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7985028 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within antigen processing and presentation IDA
IDA: Inferred from direct assay
9432982 MGI
acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
IDA: Inferred from direct assay
7679955 MGI
acts upstream of or within antigen processing and presentation of peptide antigen IDA
IDA: Inferred from direct assay
11069069 MGI
acts upstream of or within immune response IMP
IMP: Inferred from mutant phenotype
1909605 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
7679955 MGI
part of MHC class II protein complex IDA
IDA: Inferred from direct assay
7679955 MGI
located in early endosome IDA
IDA: Inferred from direct assay
11854359 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
7679955 MGI
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
8890155 MGI
located in membrane IDA
IDA: Inferred from direct assay
7584146 MGI
located in multivesicular body IDA
IDA: Inferred from direct assay
11854359 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
7679955 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histocompatibility 2, class II antigen A, beta 1

  • H-2 class II histocompatibility antigen, A beta chain

  • MHC class II H2-IA-beta-psi

  • histocompatibility 2, class II antigen A, beta, promoter 1

  • major histocompatibility complex class II beta chain

  • response to metastatic cancers 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05954 H2AB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown