H2-Ab1 - histocompatibility 2, class II antigen A, beta 1 Gene

Mus musculus

Also known as IAb; Ia2; Ia-2; Abeta; H-2Ab; H2-Ab; Rmcs1; I-Abeta

Gene ID: 14961 | Gene type: protein coding

About H2-Ab1

Summary

Enables several functions, including peptide antigen binding activity; protein antigen binding activity; and toxic substance binding activity. Involved in several processes, including B cell affinity maturation; cellular response to interferon-gamma; and positive regulation of T-helper 1 type immune response. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II and immune response. Located in Golgi apparatus; endosome; and external side of plasma membrane. Is integral component of membrane. Part of MHC class II protein complex. Is expressed in lung; metanephros; and thymus primordium. Orthologous to human HLA-DQB2 (major histocompatibility complex, class II, DQ beta 2). [provided by Alliance of Genome Resources, Apr 2022]

H2-Ab1 Products(1)

mRNA	Protein	Name
NM_207105.3	NP_996988.2	histocompatibility 2, class II antigen A, beta 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables peptide antigen binding	IDA IDA: Inferred from direct assay	9432982	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7985028	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within antigen processing and presentation	IDA IDA: Inferred from direct assay	9432982	MGI
acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II	IDA IDA: Inferred from direct assay	7679955	MGI
acts upstream of or within antigen processing and presentation of peptide antigen	IDA IDA: Inferred from direct assay	11069069	MGI
acts upstream of or within immune response	IMP IMP: Inferred from mutant phenotype	1909605	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	7679955	MGI
part of MHC class II protein complex	IDA IDA: Inferred from direct assay	7679955	MGI
located in early endosome	IDA IDA: Inferred from direct assay	11854359	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	7679955	MGI
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	8890155	MGI
located in membrane	IDA IDA: Inferred from direct assay	7584146	MGI
located in multivesicular body	IDA IDA: Inferred from direct assay	11854359	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	7679955	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

histocompatibility 2, class II antigen A, beta 1

H-2 class II histocompatibility antigen, A beta chain	MHC class II H2-IA-beta-psi
histocompatibility 2, class II antigen A, beta, promoter 1	major histocompatibility complex class II beta chain
response to metastatic cancers 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05954	H2AB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Name
Email *

	Sorry, but the email address you supplied was invalid.