H2-Eb1 - histocompatibility 2, class II antigen E beta Gene

Also Known as Eb; Ia4; H2Eb; Ia-4; H-2Eb

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14969

Summary

Predicted to enable several functions, including MHC class II receptor activity; peptide antigen binding activity; and signaling receptor binding activity. Involved in response to interferon-gamma. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II. Predicted to be located in external side of plasma membrane and immunological synapse. Predicted to be part of MHC class II protein complex. Predicted to be active in late endosome membrane and lysosomal membrane. Is expressed in lung. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); Bacterial infectious disease (multiple); eye disease (multiple); and sarcoidosis (multiple). Orthologous to human HLA-DRB1 (major histocompatibility complex, class II, DR beta 1) and HLA-DRB5 (major histocompatibility complex, class II, DR beta 5). [provided by Alliance of Genome Resources, Apr 2022]

H2-Eb1 Products (2)

mRNA Protein Name
NM_010382.2 NP_034512.2 H-2 class II histocompatibility antigen, I-E beta chain precursor
NM_010382.2 NP_034512.2 H-2 class II histocompatibility antigen, I-E beta chain precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11591653 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
IDA: Inferred from direct assay
11027433 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

H-2 class II histocompatibility antigen, I-E beta chain

  • I-E beta MHC class II

  • MHC H2-IE-beta cell surface glycoprotein

  • MHC class II IE-b

  • cell surface glycoprotein

  • histocompatibility 2, class II antigen E beta, promoter 1

  • major histocompatibility complex H-2E beta chain