H2-K1 - histocompatibility 2, K1, K region Gene

Also Known as K-f; H-2K; H2-K; H2-D1; H-2K(d)

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14972

Summary

Enables MHC class I protein binding activity and peptide antigen binding activity. Acts upstream of or within several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I; and positive regulation of T cell mediated cytotoxicity. Located in external side of plasma membrane. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and retina. Used to study myositis. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); eye disease (multiple); human immunodeficiency virus infectious disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-A (major histocompatibility complex, class I, A); HLA-E (major histocompatibility complex, class I, E); and HLA-F (major histocompatibility complex, class I, F). [provided by Alliance of Genome Resources, Apr 2022]

H2-K1 Products (8)

mRNA Protein Name
NM_001001892.3 NP_001001892.2 H-2 class I histocompatibility antigen, K-W28 alpha chain isoform 1 precursor
NM_001347346.2 NP_001334275.1 H-2 class I histocompatibility antigen, K-W28 alpha chain isoform 2 precursor
NM_001403362.1 NP_001390291.1 H-2 class I histocompatibility antigen, K-W28 alpha chain isoform 3 precursor
NM_001403363.1 NP_001390292.1 H-2 class I histocompatibility antigen, K-W28 alpha chain isoform 4 precursor
NM_001001892.3 NP_001001892.2 H-2 class I histocompatibility antigen, K-W28 alpha chain isoform 1 precursor
NM_001347346.2 NP_001334275.1 H-2 class I histocompatibility antigen, K-W28 alpha chain isoform 2 precursor
NM_001403362.1 NP_001390291.1 H-2 class I histocompatibility antigen, K-W28 alpha chain isoform 3 precursor
NM_001403363.1 NP_001390292.1 H-2 class I histocompatibility antigen, K-W28 alpha chain isoform 4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables peptide antigen binding IDA
IDA: Inferred from direct assay
16461341 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22522491 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of T cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
1538753 MGI
acts upstream of or within antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent IDA
IDA: Inferred from direct assay
1538753 MGI
acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class I IDA
IDA: Inferred from direct assay
16461341 MGI
acts upstream of or within defense response to bacterium IDA
IDA: Inferred from direct assay
16461341 MGI
acts upstream of or within inner ear development IDA
IDA: Inferred from direct assay
21795542 MGI
acts upstream of or within negative regulation of neuron projection development IDA
IDA: Inferred from direct assay
20018625 MGI
acts upstream of or within negative regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
20018625 MGI
acts upstream of or within positive regulation of T cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
1538753 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
1538753 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

H-2 class I histocompatibility antigen, K-W28 alpha chain

  • H-2 class I histocompatibility antigen, K-B alpha chain

  • H-2 class I histocompatibility antigen, K-D alpha chain

  • H-2 class I histocompatibility antigen, K-K alpha chain

  • H-2 class I histocompatibility antigen, K-Q alpha chain

  • H-2K(B)

  • H-2K(K)

  • H-2K(Q)

H2-K1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810802 Mouse MHC Class I (H-2Kb) Antibody (YA10045) ICC/IF, FC Mouse
HY-P810803 Mouse MHC Class I (H-2Kd) Antibody (YA10046) ICC/IF, FC Mouse

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-181877 IHCH-3185 / Unkown