H2-DMa - histocompatibility 2, class II, locus DMa Gene

Also Known as H-2Ma; H2-Ma

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14998

Summary

Predicted to enable MHC class II protein complex binding activity. Involved in positive regulation of germinal center formation and positive regulation of humoral immune response. Acts upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; chaperone cofactor-dependent protein refolding; and positive thymic T cell selection. Located in endosome membrane; lysosomal membrane; and multivesicular body. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human HLA-DMA (major histocompatibility complex, class II, DM alpha). [provided by Alliance of Genome Resources, Apr 2022]

H2-DMa Products (4)

mRNA Protein Name
NM_001360530.1 NP_001347459.1 class II histocompatibility antigen, M alpha chain precursor
NM_010386.4 NP_034516.3 class II histocompatibility antigen, M alpha chain precursor
NM_001360530.1 NP_001347459.1 class II histocompatibility antigen, M alpha chain precursor
NM_010386.4 NP_034516.3 class II histocompatibility antigen, M alpha chain precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9768758 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within antigen processing and presentation IDA
IDA: Inferred from direct assay
7584146 MGI
acts upstream of or within antigen processing and presentation IMP
IMP: Inferred from mutant phenotype
9432982 MGI
acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
IDA: Inferred from direct assay
11027433 MGI
acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II IMP
IMP: Inferred from mutant phenotype
8598040 MGI
acts upstream of or within chaperone cofactor-dependent protein refolding IDA
IDA: Inferred from direct assay
7985028 MGI
acts upstream of or within chaperone cofactor-dependent protein refolding IMP
IMP: Inferred from mutant phenotype
8598041 MGI
acts upstream of or within immunoglobulin mediated immune response IMP
IMP: Inferred from mutant phenotype
11714799 MGI
acts upstream of or within inner ear development IDA
IDA: Inferred from direct assay
21795542 MGI
acts upstream of or within positive regulation of T cell differentiation IMP
IMP: Inferred from mutant phenotype
8598040 MGI
involved in positive regulation of germinal center formation IMP
IMP: Inferred from mutant phenotype
11714799 MGI
involved in positive regulation of humoral immune response IMP
IMP: Inferred from mutant phenotype
11714799 MGI
acts upstream of or within positive regulation of immune response IMP
IMP: Inferred from mutant phenotype
11714799 MGI
acts upstream of or within positive thymic T cell selection IMP
IMP: Inferred from mutant phenotype
8598040 MGI
acts upstream of or within protein transport IDA
IDA: Inferred from direct assay
8890155 MGI
acts upstream of or within protein-containing complex assembly IDA
IDA: Inferred from direct assay
7985028 MGI
Cellular Component GO Annotation Evidence References Source
located in endosome membrane IDA
IDA: Inferred from direct assay
7985028 MGI
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
9492004 MGI
located in late endosome IDA
IDA: Inferred from direct assay
7584146 MGI
located in lysosomal membrane IDA
IDA: Inferred from direct assay
7985028 MGI
located in lysosome IDA
IDA: Inferred from direct assay
7584146 MGI
located in multivesicular body IDA
IDA: Inferred from direct assay
11854359 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

class II histocompatibility antigen, M alpha chain

  • H2-M alpha

  • MHC class II antigen DMa

  • histocompatibility 2, class II, locus Ma