H2-DMb2 - histocompatibility 2, class II, locus Mb2 Gene

Also Known as H-2Mb2; H2-Mb2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15000

Summary

Predicted to enable MHC class II protein complex binding activity. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II and chaperone cofactor-dependent protein refolding. Located in endosome membrane; lysosomal membrane; and multivesicular body. Is integral component of membrane. Orthologous to human HLA-DMB (major histocompatibility complex, class II, DM beta). [provided by Alliance of Genome Resources, Apr 2022]

H2-DMb2 Products (2)

mRNA Protein Name
NM_010388.5 NP_034518.1 histocompatibility 2, class II, locus Mb2 precursor
NM_010388.5 NP_034518.1 histocompatibility 2, class II, locus Mb2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9768758 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within antigen processing and presentation IDA
IDA: Inferred from direct assay
7584146 MGI
acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
IDA: Inferred from direct assay
11027433 MGI
acts upstream of or within chaperone cofactor-dependent protein refolding IDA
IDA: Inferred from direct assay
11148202 MGI
Cellular Component GO Annotation Evidence References Source
located in endosome membrane IDA
IDA: Inferred from direct assay
7584146 MGI
located in late endosome IDA
IDA: Inferred from direct assay
7584146 MGI
located in lysosomal membrane IDA
IDA: Inferred from direct assay
7584146 MGI
located in lysosome IDA
IDA: Inferred from direct assay
11854359 MGI
located in membrane IDA
IDA: Inferred from direct assay
7584146 MGI
located in multivesicular body IDA
IDA: Inferred from direct assay
11854359 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histocompatibility 2, class II, locus Mb2

  • H2-M beta2

  • MHC class II antigen Mb2