TTL - tubulin tyrosine ligase Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 150465

About TTL

Cytogenetic location: 2q14.1 Genomic coordinates (GRCh38): 2:112,482,156-112,541,739 (from NCBI)

This gene has 4 transcripts (splice variants) and 176 orthologues. Ubiquitous expression in brain (RPKM 13.3), lung (RPKM 7.4) and 24 other tissues.

Summary

TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).[supplied by OMIM, Mar 2008]

TTL Products (2)

mRNA Protein Name
NM_001371712.1 NP_001358641.1 tubulin--tyrosine ligase isoform 2
NM_153712.5 NP_714923.1 tubulin--tyrosine ligase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables tubulin-tyrosine ligase activity IMP
IMP: Inferred from mutant phenotype
25908662 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
25908662 GOA
involved in post-translational protein modification IMP
IMP: Inferred from mutant phenotype
25908662 GOA
involved in regulation of metaphase plate congression IMP
IMP: Inferred from mutant phenotype
25908662 GOA
Cellular Component GO Annotation Evidence References Source
located in spindle microtubule IDA
IDA: Inferred from direct assay
25908662 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TTL Protein Structure

TTL

TTL: Tubulin-tyrosine ligase family (85 - 366)

  • 0
  • 100
  • 200
  • 300
  • 377 a.a.
Protein Preferred Names Protein Names

tubulin--tyrosine ligase

  • 2410003M22Rik

Related Diseases

Diseases Alias
Fundus Dystrophy

  • Retinal Dystrophy

  • Retinal Dystrophies

  • Dystrophy, Retinal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15227 TTL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19569 Ttl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26066 Ttl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TTL VGNC VGNC:47972
Felis catus TTL VGNC VGNC:66684
Rattus norvegicus TTL RGD RGD:621113
Mus musculus TTL MGD MGI:1916987
Bos taurus TTL VGNC VGNC:36488
Others TTL NCBI