PLB1 - phospholipase B1 Gene

Also Known as PLB; PLB/LIP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 151056

About PLB1

Cytogenetic location: 2p23.2 Genomic coordinates (GRCh38): 2:28,496,060-28,644,142 (from NCBI)

This gene has 12 transcripts (splice variants) and 211 orthologues. Biased expression in small intestine (RPKM 8.9), bone marrow (RPKM 1.8) and 8 other tissues.

Summary

This gene encodes a membrane-associated Phospholipase that displays lysophospholipase and Phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays Lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail. This gene has been identified as a candidate rheumatoid arthritis risk gene. [provided by RefSeq, Jul 2016]

PLB1 Products (2)

mRNA	Protein	Name
NM_001170585.2	NP_001164056.1	phospholipase B1, membrane-associated isoform 2 precursor
NM_153021.5	NP_694566.4	phospholipase B1, membrane-associated isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLB1 Protein Structure

Lipase_GDSL

0
300
600
900
1200
1458 a.a.

Protein Preferred Names	Protein Names
phospholipase B1, membrane-associated	lysophospholipase

Related Diseases

Diseases	Alias
Fungal Meningitis	Meningitis, Fungal Mycotic Meningitis
Denture Stomatitis	Stomatitis, Denture Denture Sore Mouth
Cryptococcal Meningitis	Meningitis, Cryptococcal Meningitis Cryptococcal
Cryptococcosis	Cryptococcus Neoformans Infection Torulosis Busse-Buschke'S Disease Cryptococcal Infection European Cryptococcosis Torula Infection By Cryptococcus Neoformans Cryptococcosis Infection European Blastomycosis European Blastomycotic Infection European Blastomycoses Infection Torula Histolytica Infection
Mucinous Bronchioloalveolar Adenocarcinoma	Bronchiolo-Alveolar Carcinoma, Mucinous
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Opportunistic Mycosis	Opportunistic Mycoses Opportunistic Systemic Mycoses
Fungal Infectious Disease	Mycoses Mycosis
Amyotrophic Lateral Sclerosis Type 6	Amyotrophic Lateral Sclerosis 6, Autosomal Recessive Als6 Amyotrophic Lateral Sclerosis 6, With Or Without Frontotemporal Dementia Autosomal Recessive Amyotrophic Lateral Sclerosis 6 Sclerosis, Lateral, Amyotrophic, Type Type 6 Amyotrophic Lateral Sclerosis 6
Meningoencephalitis	Acquired Toxoplasmal Meningoencephalitis Meningoencephalitis Due To Acquired Toxoplasmosis Meningoencephalitis Due To Toxoplasmosis Toxoplasma Meningoencephalitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10649	PLB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PLB1	VGNC	VGNC:76137
Bos taurus	PLB1	VGNC	VGNC:32977
Felis catus	PLB1	VGNC	VGNC:64205
Rattus norvegicus	PLB1	RGD	RGD:621565
Mus musculus	PLB1	MGD	MGI:1922406
Canis familiaris	PLB1	VGNC	VGNC:44641
Others	PLB1	NCBI