PLB1 - phospholipase B1 Gene

Homo sapiens

Also known as PLB; PLB/LIP

Gene ID: 151056 | Gene type: protein coding

About PLB1

Cytogenetic location: 2p23.2 Genomic coordinates (GRCh38): 2:28,496,060-28,644,142 (from NCBI)

This gene has 12 transcripts (splice variants) and 211 orthologues. Biased expression in small intestine (RPKM 8.9), bone marrow (RPKM 1.8) and 8 other tissues.

Summary

This gene encodes a membrane-associated Phospholipase that displays lysophospholipase and Phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays Lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the Enzyme to the membrane and a short C-terminal cytoplasmic tail. This gene has been identified as a candidate rheumatoid arthritis risk gene. [provided by RefSeq, Jul 2016]

PLB1 Products(2)

mRNA	Protein	Name
NM_001170585.2	NP_001164056.1	phospholipase B1, membrane-associated isoform 2 precursor
NM_153021.5	NP_694566.4	phospholipase B1, membrane-associated isoform 1 precursor

PLB1 Protein Structure

Lipase_GDSL

0
300
600
900
1200
1458 a.a.

Protein Preferred Names

Protein Names

phospholipase B1, membrane-associated

lysophospholipase

Related Diseases

Diseases

Alias

Fungal Meningitis

Meningitis, Fungal

Mycotic Meningitis

Denture Stomatitis

Stomatitis, Denture

Denture Sore Mouth

Cryptococcal Meningitis

Meningitis, Cryptococcal

Meningitis Cryptococcal

Cryptococcosis

Cryptococcus Neoformans Infection	Torulosis
Busse-Buschke'S Disease	Cryptococcal Infection
European Cryptococcosis	Torula
Infection By Cryptococcus Neoformans	Cryptococcosis Infection
European Blastomycosis	European Blastomycotic Infection
European Blastomycoses Infection	Torula Histolytica Infection

Mucinous Bronchioloalveolar Adenocarcinoma

Bronchiolo-Alveolar Carcinoma, Mucinous

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Opportunistic Mycosis

Opportunistic Mycoses

Opportunistic Systemic Mycoses

Fungal Infectious Disease

Mycoses

Mycosis

Amyotrophic Lateral Sclerosis Type 6

Amyotrophic Lateral Sclerosis 6, Autosomal Recessive	Als6
Amyotrophic Lateral Sclerosis 6, With Or Without Frontotemporal Dementia	Autosomal Recessive Amyotrophic Lateral Sclerosis 6
Sclerosis, Lateral, Amyotrophic, Type Type 6	Amyotrophic Lateral Sclerosis 6

Meningoencephalitis

Acquired Toxoplasmal Meningoencephalitis	Meningoencephalitis Due To Acquired Toxoplasmosis
Meningoencephalitis Due To Toxoplasmosis	Toxoplasma Meningoencephalitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10649	PLB1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PLB1	VGNC	VGNC:76137
Bos taurus	PLB1	VGNC	VGNC:32977
Felis catus	PLB1	VGNC	VGNC:64205
Rattus norvegicus	PLB1	RGD	RGD:621565
Mus musculus	PLB1	MGD	MGI:1922406
Canis familiaris	PLB1	VGNC	VGNC:44641