Hand1 - heart and neural crest derivatives expressed 1 Gene

Also Known as Hxt; Th1; eHAND; Ehand1; Thing1; bHLHa27

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15110

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; protein homodimerization activity; and transcription coregulator binding activity. Acts upstream of or within several processes, including animal organ development; mesoderm formation; and regulation of transcription, DNA-templated. Located in nucleolus and nucleoplasm. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; heart and pericardium; and nervous system. Used to study hypoplastic left heart syndrome. Orthologous to human HAND1 (heart and neural crest derivatives expressed 1). [provided by Alliance of Genome Resources, Apr 2022]

Hand1 Products (1)

mRNA Protein Name
NM_008213.2 NP_032239.1 heart- and neural crest derivatives-expressed protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
15509787 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15509787 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IGI
IGI: Inferred from genetic interaction
10611232 MGI
enables bHLH transcription factor binding IPI
IPI: Inferred from physical interaction
10611232 MGI
enables enzyme binding IPI
IPI: Inferred from physical interaction
17891141 MGI
enables identical protein binding IDA
IDA: Inferred from direct assay
23911935 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
10924525 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10924525 MGI
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
10924525 MGI
enables sequence-specific DNA binding IGI
IGI: Inferred from genetic interaction
12070084 MGI
enables transcription coregulator binding IPI
IPI: Inferred from physical interaction
15509787 MGI
enables transcription factor binding IPI
IPI: Inferred from physical interaction
7814632 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
15073150 MGI
acts upstream of or within cartilage morphogenesis IGI
IGI: Inferred from genetic interaction
17764670 MGI
acts upstream of or within cell differentiation IGI
IGI: Inferred from genetic interaction
16759287 MGI
acts upstream of or within determination of heart left/right asymmetry IMP
IMP: Inferred from mutant phenotype
11076684 MGI
acts upstream of or within embryonic heart tube development IMP
IMP: Inferred from mutant phenotype
9500551 MGI
acts upstream of or within embryonic heart tube formation IMP
IMP: Inferred from mutant phenotype
11076684 MGI
acts upstream of or within heart development IGI
IGI: Inferred from genetic interaction
15576406 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
9500550 MGI
acts upstream of or within heart looping IMP
IMP: Inferred from mutant phenotype
9500551 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
9500551 MGI
acts upstream of or within mesenchyme development IGI
IGI: Inferred from genetic interaction
17764670 MGI
acts upstream of or within mesoderm formation IMP
IMP: Inferred from mutant phenotype
9500550 MGI
acts upstream of or within negative regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
19144722 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16759287 MGI
involved in negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
10611232 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IGI
IGI: Inferred from genetic interaction
17764670 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15509787 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15509787 MGI
involved in positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
10611232 MGI
acts upstream of or within trophoblast giant cell differentiation IDA
IDA: Inferred from direct assay
23911935 MGI
involved in trophoblast giant cell differentiation IMP
IMP: Inferred from mutant phenotype
10611232 MGI
acts upstream of or within ventricular cardiac muscle tissue morphogenesis IMP
IMP: Inferred from mutant phenotype
9500551 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleolus IDA
IDA: Inferred from direct assay
17891141 MGI
located in nucleoplasm IDA
IDA: Inferred from direct assay
17891141 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15509787 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

heart- and neural crest derivatives-expressed protein 1

  • extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1

  • heart and neural crest derivatives expressed transcript 1

  • helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05996 HAND1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181888 GRL-142 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hand1 NCBI NCBI:9421