Hand1 - heart and neural crest derivatives expressed 1 Gene

Mus musculus

Also known as Hxt; Th1; eHAND; Ehand1; Thing1; bHLHa27

Gene ID: 15110 | Gene type: protein coding

About Hand1

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; protein homodimerization activity; and transcription coregulator binding activity. Acts upstream of or within several processes, including animal organ development; mesoderm formation; and regulation of transcription, DNA-templated. Located in nucleolus and nucleoplasm. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; heart and pericardium; and nervous system. Used to study hypoplastic left heart syndrome. Orthologous to human HAND1 (heart and neural crest derivatives expressed 1). [provided by Alliance of Genome Resources, Apr 2022]

Hand1 Products(1)

mRNA	Protein	Name
NM_008213.2	NP_032239.1	heart- and neural crest derivatives-expressed protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15509787	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15509787	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IGI IGI: Inferred from genetic interaction	10611232	MGI
enables bHLH transcription factor binding	IPI IPI: Inferred from physical interaction	10611232	MGI
enables enzyme binding	IPI IPI: Inferred from physical interaction	17891141	MGI
enables identical protein binding	IDA IDA: Inferred from direct assay	23911935	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	10924525	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10924525	MGI
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	10924525	MGI
enables sequence-specific DNA binding	IGI IGI: Inferred from genetic interaction	12070084	MGI
enables transcription coregulator binding	IPI IPI: Inferred from physical interaction	15509787	MGI
enables transcription factor binding	IPI IPI: Inferred from physical interaction	7814632	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	15073150	MGI
acts upstream of or within cartilage morphogenesis	IGI IGI: Inferred from genetic interaction	17764670	MGI
acts upstream of or within cell differentiation	IGI IGI: Inferred from genetic interaction	16759287	MGI
acts upstream of or within determination of heart left/right asymmetry	IMP IMP: Inferred from mutant phenotype	11076684	MGI
acts upstream of or within embryonic heart tube development	IMP IMP: Inferred from mutant phenotype	9500551	MGI
acts upstream of or within embryonic heart tube formation	IMP IMP: Inferred from mutant phenotype	11076684	MGI
acts upstream of or within heart development	IGI IGI: Inferred from genetic interaction	15576406	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	9500550	MGI
acts upstream of or within heart looping	IMP IMP: Inferred from mutant phenotype	9500551	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	9500551	MGI
acts upstream of or within mesenchyme development	IGI IGI: Inferred from genetic interaction	17764670	MGI
acts upstream of or within mesoderm formation	IMP IMP: Inferred from mutant phenotype	9500550	MGI
acts upstream of or within negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	19144722	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16759287	MGI
involved in negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	10611232	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IGI IGI: Inferred from genetic interaction	17764670	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15509787	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15509787	MGI
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	10611232	MGI
acts upstream of or within trophoblast giant cell differentiation	IDA IDA: Inferred from direct assay	23911935	MGI
involved in trophoblast giant cell differentiation	IMP IMP: Inferred from mutant phenotype	10611232	MGI
acts upstream of or within ventricular cardiac muscle tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	9500551	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleolus	IDA IDA: Inferred from direct assay	17891141	MGI
located in nucleoplasm	IDA IDA: Inferred from direct assay	17891141	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15509787	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

heart- and neural crest derivatives-expressed protein 1

extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1	heart and neural crest derivatives expressed transcript 1
helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05996	HAND1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-181888	GRL-142	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hand1	NCBI	NCBI:9421

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