GPR155 - G protein-coupled receptor 155 Gene

Also Known as DEP.7; PGR22; DEPDC3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 151556

About GPR155

This gene has 6 transcripts (splice variants), 274 orthologues and 3 paralogues. Ubiquitous expression in stomach (RPKM 11.2), brain (RPKM 8.6) and 24 other tissues.

Summary

Involved in cognition. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

GPR155 Products (4)

mRNA Protein Name
NM_001033045.4 NP_001028217.1 integral membrane protein GPR155 isoform 1
NM_001267050.2 NP_001253979.1 integral membrane protein GPR155 isoform 1
NM_001267051.2 NP_001253980.1 integral membrane protein GPR155 isoform 2
NM_152529.7 NP_689742.4 integral membrane protein GPR155 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cholesterol binding IDA
IDA: Inferred from direct assay
36007018 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to amino acid starvation IDA
IDA: Inferred from direct assay
36007018 GOA
involved in cellular response to cholesterol IDA
IDA: Inferred from direct assay
36007018 GOA
involved in cognition IMP
IMP: Inferred from mutant phenotype
17519220 GOA
involved in positive regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
36007018 GOA
Cellular Component GO Annotation Evidence References Source
is active in lysosomal membrane IDA
IDA: Inferred from direct assay
36007018 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR155 Protein Structure

Mem_trans

Mem_trans: Membrane transport protein (45 - 189)

Mem_trans

Mem_trans: Membrane transport protein (204 - 360)

DEP

DEP: Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) (767 - 833)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 870 a.a.
Protein Preferred Names Protein Names

integral membrane protein GPR155

  • G-protein coupled receptor PGR22

Related Diseases

Diseases Alias
Noonan Syndrome 13

  • NS13
Isolated Growth Hormone Deficiency, Type Ib

  • Isolated Growth Hormone Deficiency Type Ib

  • IGHD1B

  • Ighd Ib

  • Growth Hormone Deficiency, Isolated, Type Ib

  • Congenital Ighd Type Ib

  • Congenital Isolated Gh Deficiency Type Ib

  • Congenital Isolated Growth Hormone Deficiency Type Ib

  • Dwarfism Of Sindh

  • Pituitary Dwarfism I

  • Isolated Growth Hormone Deficiency Type 1b

  • Ighd 1b

  • Growth Hormone Deficiency, Isolated, 1b
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05672 GPR155 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GPR155 VGNC VGNC:72985
Felis catus GPR155 VGNC VGNC:62680
Rattus norvegicus GPR155 RGD RGD:1309162
Bos taurus GPR155 VGNC VGNC:29561
Canis familiaris GPR155 VGNC VGNC:41407
Mus musculus GPR155 MGD MGI:1915776
Others GPR155 NCBI