EFHB - EF-hand domain family member B Gene

Also Known as CFAP21

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 151651

About EFHB

This gene has 7 transcripts (splice variants), 139 orthologues and 2 paralogues. Biased expression in testis (RPKM 7.6), lung (RPKM 1.1) and 1 other tissue.

Summary

Enables calcium ion sensor activity. Involved in negative regulation of protein binding activity; regulation of calcineurin-NFAT signaling cascade; and regulation of store-operated calcium entry. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

EFHB Products (2)

mRNA Protein Name
NM_001330688.2 NP_001317617.1 EF-hand domain-containing family member B isoform 2
NM_144715.4 NP_653316.3 EF-hand domain-containing family member B isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion sensor activity IMP
IMP: Inferred from mutant phenotype
30481768 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
30481768 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of protein binding IMP
IMP: Inferred from mutant phenotype
30481768 GOA
involved in regulation of calcineurin-NFAT signaling cascade IMP
IMP: Inferred from mutant phenotype
30481768 GOA
involved in regulation of store-operated calcium entry IMP
IMP: Inferred from mutant phenotype
30481768 GOA
Cellular Component GO Annotation Evidence References Source
located in axonemal microtubule IDA
IDA: Inferred from direct assay
36191189 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EFHB Protein Structure

EF-hand_7

EF-hand_7: EF-hand domain pair (567 - 625)

  • 0
  • 200
  • 400
  • 600
  • 833 a.a.
Protein Preferred Names Protein Names

EF-hand domain-containing family member B

  • cilia and flagella associated protein 21

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04187 EFHB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris EFHB VGNC VGNC:40222
Bos taurus EFHB VGNC VGNC:28350
Macaca mulatta EFHB VGNC VGNC:72118
Mus musculus EFHB MGD MGI:3045296
Felis catus EFHB VGNC VGNC:61745
Rattus norvegicus EFHB RGD RGD:1566407
Others EFHB NCBI