Hesx1 - homeobox gene expressed in ES cells Gene

Mus musculus

Also known as Rpx; HES-1

Gene ID: 15209 | Gene type: protein coding

About Hesx1

Summary

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; protein C-terminus binding activity; and protein homodimerization activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within with a negative effect on canonical Wnt signaling pathway. Acts upstream of or within several processes, including ERK1 and ERK2 cascade; animal organ development; and cell surface receptor signaling pathway. Located in nucleus. Is expressed in several structures, including early conceptus; embryo ectoderm; embryo endoderm; genitourinary system; and thymus. Used to study hypopituitarism and septooptic dysplasia. Human ortholog(s) of this gene implicated in septooptic dysplasia. Orthologous to human HESX1 (HESX homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Hesx1 Products(1)

mRNA	Protein	Name
NM_010420.2	NP_034550.2	homeobox expressed in ES cells 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17445765	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17445765	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17445765	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	16678101	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17931718	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	12063185	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12063185	MGI
enables sequence-specific double-stranded DNA binding	IMP IMP: Inferred from mutant phenotype	11748154	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	31761678	MGI
acts upstream of or within Wnt signaling pathway	IDA IDA: Inferred from direct assay	24520934	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	11291863	MGI
acts upstream of or within camera-type eye development	IMP IMP: Inferred from mutant phenotype	19093031	MGI
acts upstream of or within negative effect canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	17360769	MGI
acts upstream of or within cellular response to cadmium ion	IDA IDA: Inferred from direct assay	15219627	MGI
acts upstream of or within forebrain development	IDA IDA: Inferred from direct assay	24520934	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	9620767	MGI
acts upstream of or within forebrain morphogenesis	IMP IMP: Inferred from mutant phenotype	9620767	MGI
acts upstream of or within gene expression	IDA IDA: Inferred from direct assay	26188092	MGI
acts upstream of or within negative effect gene expression	IDA IDA: Inferred from direct assay	12063185	MGI
acts upstream of or within gonad development	IGI IGI: Inferred from genetic interaction	18775421	MGI
acts upstream of or within leukemia inhibitory factor signaling pathway	IMP IMP: Inferred from mutant phenotype	31761678	MGI
acts upstream of or within multicellular organism growth	IGI IGI: Inferred from genetic interaction	18775421	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17931718	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17445765	MGI
acts upstream of or within nose development	IMP IMP: Inferred from mutant phenotype	9620767	MGI
acts upstream of or within otic vesicle formation	IMP IMP: Inferred from mutant phenotype	9620767	MGI
acts upstream of or within pituitary gland development	IGI IGI: Inferred from genetic interaction	18775421	MGI
acts upstream of or within pituitary gland development	IMP IMP: Inferred from mutant phenotype	9620767	MGI
acts upstream of or within regulation of embryonic development	IMP IMP: Inferred from mutant phenotype	31761678	MGI
acts upstream of or within stem cell differentiation	IMP IMP: Inferred from mutant phenotype	31761678	MGI
acts upstream of or within stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	26188092	MGI
acts upstream of or within thyroid gland development	IGI IGI: Inferred from genetic interaction	18775421	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	17931718	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

homeobox expressed in ES cells 1

anterior-restricted homeobox protein	homeo box gene expressed in ES cells
homeobox protein ANF	rathke pouch homeo box

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06141	HESX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hesx1	NCBI	NCBI:8820

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