Hesx1 - homeobox gene expressed in ES cells Gene

Also Known as Rpx; HES-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15209

Summary

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; protein C-terminus binding activity; and protein homodimerization activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within with a negative effect on canonical Wnt signaling pathway. Acts upstream of or within several processes, including ERK1 and ERK2 cascade; animal organ development; and cell surface receptor signaling pathway. Located in nucleus. Is expressed in several structures, including early conceptus; embryo ectoderm; embryo endoderm; genitourinary system; and thymus. Used to study hypopituitarism and septooptic dysplasia. Human ortholog(s) of this gene implicated in septooptic dysplasia. Orthologous to human HESX1 (HESX homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Hesx1 Products (1)

mRNA Protein Name
NM_010420.2 NP_034550.2 homeobox expressed in ES cells 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
17445765 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17445765 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17445765 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
16678101 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17931718 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
12063185 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12063185 MGI
enables sequence-specific double-stranded DNA binding IMP
IMP: Inferred from mutant phenotype
11748154 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
31761678 MGI
acts upstream of or within Wnt signaling pathway IDA
IDA: Inferred from direct assay
24520934 MGI
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
11291863 MGI
acts upstream of or within camera-type eye development IMP
IMP: Inferred from mutant phenotype
19093031 MGI
acts upstream of or within negative effect canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
17360769 MGI
acts upstream of or within cellular response to cadmium ion IDA
IDA: Inferred from direct assay
15219627 MGI
acts upstream of or within forebrain development IDA
IDA: Inferred from direct assay
24520934 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
9620767 MGI
acts upstream of or within forebrain morphogenesis IMP
IMP: Inferred from mutant phenotype
9620767 MGI
acts upstream of or within gene expression IDA
IDA: Inferred from direct assay
26188092 MGI
acts upstream of or within negative effect gene expression IDA
IDA: Inferred from direct assay
12063185 MGI
acts upstream of or within gonad development IGI
IGI: Inferred from genetic interaction
18775421 MGI
acts upstream of or within leukemia inhibitory factor signaling pathway IMP
IMP: Inferred from mutant phenotype
31761678 MGI
acts upstream of or within multicellular organism growth IGI
IGI: Inferred from genetic interaction
18775421 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
17931718 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17445765 MGI
acts upstream of or within nose development IMP
IMP: Inferred from mutant phenotype
9620767 MGI
acts upstream of or within otic vesicle formation IMP
IMP: Inferred from mutant phenotype
9620767 MGI
acts upstream of or within pituitary gland development IGI
IGI: Inferred from genetic interaction
18775421 MGI
acts upstream of or within pituitary gland development IMP
IMP: Inferred from mutant phenotype
9620767 MGI
acts upstream of or within regulation of embryonic development IMP
IMP: Inferred from mutant phenotype
31761678 MGI
acts upstream of or within stem cell differentiation IMP
IMP: Inferred from mutant phenotype
31761678 MGI
acts upstream of or within stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
26188092 MGI
acts upstream of or within thyroid gland development IGI
IGI: Inferred from genetic interaction
18775421 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
17931718 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox expressed in ES cells 1

  • anterior-restricted homeobox protein

  • homeo box gene expressed in ES cells

  • homeobox protein ANF

  • rathke pouch homeo box

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06141 HESX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hesx1 NCBI NCBI:8820