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Hey2 - hairy/enhancer-of-split related with YRPW motif 2 Gene

Also Known as CHF1; Hrt2; Herp1; hesr2; bHLHb32

Species: Mus musculus

Gene Type: protein coding

Gene ID: 15214

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding activity; and sequence-specific DNA binding activity. Involved in several processes, including circulatory system development; regulation of gene expression; and umbilical cord morphogenesis. Acts upstream of or within several processes, including cardiac muscle hypertrophy in response to stress; circulatory system development; and negative regulation of cardiac muscle cell apoptotic process. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study aortic valve disease and tetralogy of Fallot. Orthologous to human HEY2 (hes related family bHLH transcription factor with YRPW motif 2). [provided by Alliance of Genome Resources, Apr 2022]

Hey2 Products (1)

mRNA	Protein	Name
NM_013904.1	NP_038932.1	hairy/enhancer-of-split related with YRPW motif protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IMP IMP: Inferred from mutant phenotype	11095750	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15485867	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	16199874	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18239137	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	11076679	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11076679	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22615585	MGI
enables transcription factor binding	IPI IPI: Inferred from physical interaction	16603706	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in Notch signaling pathway	IDA IDA: Inferred from direct assay	10964718	MGI
involved in Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	12372254	MGI
acts upstream of or within anterior/posterior axis specification	IGI IGI: Inferred from genetic interaction	15680351	MGI
involved in aortic valve morphogenesis	IDA IDA: Inferred from direct assay	22110751	MGI
involved in arterial endothelial cell differentiation	IGI IGI: Inferred from genetic interaction	15107403	MGI
acts upstream of or within artery development	IGI IGI: Inferred from genetic interaction	15680351	MGI
involved in ascending aorta morphogenesis	IMP IMP: Inferred from mutant phenotype	12372254	MGI
involved in atrial septum morphogenesis	IMP IMP: Inferred from mutant phenotype	12372254	MGI
acts upstream of or within atrioventricular valve development	IMP IMP: Inferred from mutant phenotype	15297376	MGI
acts upstream of or within blood vessel development	IGI IGI: Inferred from genetic interaction	15680351	MGI
acts upstream of or within blood vessel endothelial cell differentiation	IGI IGI: Inferred from genetic interaction	15107403	MGI
involved in cardiac epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	17303760	MGI
involved in cardiac left ventricle morphogenesis	IMP IMP: Inferred from mutant phenotype	12372254	MGI
acts upstream of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	20382855	MGI
acts upstream of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	17332425	MGI
acts upstream of or within cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	20382855	MGI
acts upstream of or within cardiac muscle hypertrophy in response to stress	IDA IDA: Inferred from direct assay	16603706	MGI
involved in cardiac right ventricle morphogenesis	IMP IMP: Inferred from mutant phenotype	12372254	MGI
involved in cardiac septum morphogenesis	IMP IMP: Inferred from mutant phenotype	17259303	MGI
acts upstream of or within cardiac vascular smooth muscle cell development	IMP IMP: Inferred from mutant phenotype	20619341	MGI
involved in cardiac ventricle morphogenesis	IMP IMP: Inferred from mutant phenotype	16199874	MGI
acts upstream of or within cell fate commitment	IMP IMP: Inferred from mutant phenotype	19154718	MGI
acts upstream of or within cochlea development	IGI IGI: Inferred from genetic interaction	18302773	MGI
acts upstream of or within cochlea development	IMP IMP: Inferred from mutant phenotype	18302773	MGI
acts upstream of or within coronary vasculature morphogenesis	IMP IMP: Inferred from mutant phenotype	20619341	MGI
involved in dorsal aorta morphogenesis	IGI IGI: Inferred from genetic interaction	15107403	MGI
acts upstream of or within endocardial cushion to mesenchymal transition involved in heart valve formation	IGI IGI: Inferred from genetic interaction	15680351	MGI
involved in heart trabecula formation	IMP IMP: Inferred from mutant phenotype	17259303	MGI
involved in labyrinthine layer blood vessel development	IGI IGI: Inferred from genetic interaction	15107403	MGI
involved in mesenchymal cell development	IMP IMP: Inferred from mutant phenotype	17303760	MGI
involved in muscular septum morphogenesis	IMP IMP: Inferred from mutant phenotype	12372254	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15485867	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	16199874	MGI
involved in negative regulation of Notch signaling pathway	IDA IDA: Inferred from direct assay	18239137	MGI
involved in negative regulation of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	11095750	MGI
involved in negative regulation of biomineral tissue development	IDA IDA: Inferred from direct assay	22110751	MGI
acts upstream of or within negative regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	20382855	MGI
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20382855	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16025100	MGI
involved in negative regulation of smooth muscle cell differentiation	IDA IDA: Inferred from direct assay	18239137	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10692439	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18239137	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	20628571	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16025100	MGI
involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	12372254	MGI
acts upstream of or within pattern specification process	IGI IGI: Inferred from genetic interaction	18302773	MGI
acts upstream of or within pattern specification process	IMP IMP: Inferred from mutant phenotype	18302773	MGI
acts upstream of or within positive regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	17332425	MGI
acts upstream of or within positive regulation of heart rate	IMP IMP: Inferred from mutant phenotype	15297376	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15107403	MGI
acts upstream of or within protein-DNA complex assembly	IDA IDA: Inferred from direct assay	10692439	MGI
involved in pulmonary artery morphogenesis	IMP IMP: Inferred from mutant phenotype	12372254	MGI
involved in pulmonary valve morphogenesis	IMP IMP: Inferred from mutant phenotype	12372254	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20619341	MGI
acts upstream of or within regulation of inner ear auditory receptor cell differentiation	IGI IGI: Inferred from genetic interaction	19154718	MGI
involved in regulation of vasculogenesis	IGI IGI: Inferred from genetic interaction	15107403	MGI
acts upstream of or within tricuspid valve formation	IMP IMP: Inferred from mutant phenotype	15297376	MGI
involved in tricuspid valve morphogenesis	IMP IMP: Inferred from mutant phenotype	12372254	MGI
involved in umbilical cord morphogenesis	IGI IGI: Inferred from genetic interaction	15107403	MGI
acts upstream of or within vasculogenesis	IGI IGI: Inferred from genetic interaction	15107403	MGI
involved in ventricular cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	17332425	MGI
involved in ventricular septum morphogenesis	IMP IMP: Inferred from mutant phenotype	12372254	MGI
acts upstream of or within ventricular trabecula myocardium morphogenesis	IGI IGI: Inferred from genetic interaction	15680351	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21290414	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11095750	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
hairy/enhancer-of-split related with YRPW motif protein 2	HES-related repressor protein 2 HESR-2 HRT-2 Hairy-E(spl)-related with YRPW motif 2 hairy and enhancer of split related 2 hairy and enhancer of split-related protein 2 hairy-related transcription factor 2 mHRT2 protein gridlock homolog

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06147	HEY2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hey2	NCBI	NCBI:23493