Foxd3 - forkhead box D3 Gene

Also Known as CWH3; Hfh2; Genesis

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15221

Summary

Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in in utero embryonic development and negative regulation of transcription by RNA polymerase II. Acts upstream of or within cellular response to leukemia inhibitory factor; embryonic placenta development; and trophectodermal cell differentiation. Predicted to be located in chromatin. Predicted to be part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system; and sensory organ. Human ortholog(s) of this gene implicated in vitiligo. Orthologous to human FOXD3 (forkhead box D3). [provided by Alliance of Genome Resources, Apr 2022]

Foxd3 Products (1)

mRNA Protein Name
NM_010425.3 NP_034555.3 forkhead box protein D3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
8798505 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
7958446 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of or within embryonic placenta development IMP
IMP: Inferred from mutant phenotype
16039639 MGI
involved in in utero embryonic development IDA
IDA: Inferred from direct assay
12381664 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8798505 MGI
acts upstream of or within trophectodermal cell differentiation IMP
IMP: Inferred from mutant phenotype
16039639 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

forkhead box protein D3

  • HFH-2

  • HNF-3/forkhead homolog 2

  • HNF3/FH transcription factor genesis

  • hepatocyte nuclear factor 3 forkhead homolog 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05045 FOXD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20022 Foxd3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26525 Foxd3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Foxd3 NCBI NCBI:27022