Foxg1 - forkhead box G1 Gene

Mus musculus

Also known as Bf1; BF-1; Hfh9; Hfhbf1; 2900064B05Rik

Gene ID: 15228 | Gene type: protein coding

About Foxg1

Summary

Enables sequence-specific DNA binding activity. Acts upstream of or within several processes, including generation of neurons; inner ear morphogenesis; and regulation of neuron differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; embryo endoderm; hemolymphoid system; and sensory organ. Used to study Rett syndrome. Orthologous to human FOXG1 (forkhead box G1). [provided by Alliance of Genome Resources, Apr 2022]

Foxg1 Products(2)

mRNA	Protein	Name
NM_001160112.1	NP_001153584.1	forkhead box protein G1
NM_008241.2	NP_032267.1	forkhead box protein G1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15084259	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23332764	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within axon midline choice point recognition	IMP IMP: Inferred from mutant phenotype	15240555	MGI
acts upstream of cell cycle	IMP IMP: Inferred from mutant phenotype	15893304	MGI
acts upstream of or within cell morphogenesis involved in neuron differentiation	IMP IMP: Inferred from mutant phenotype	16691564	MGI
acts upstream of or within central nervous system neuron development	IMP IMP: Inferred from mutant phenotype	16680166	MGI
acts upstream of or within cerebral cortex development	IDA IDA: Inferred from direct assay	22726835	MGI
acts upstream of or within dorsal/ventral pattern formation	IMP IMP: Inferred from mutant phenotype	14566948	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	7605629	MGI
acts upstream of or within inner ear morphogenesis	IGI IGI: Inferred from genetic interaction	16691564	MGI
acts upstream of or within inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	16691564	MGI
acts upstream of or within negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	7605629	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16314515	MGI
acts upstream of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	15893304	MGI
acts upstream of or within neurogenesis	IDA IDA: Inferred from direct assay	18184563	MGI
acts upstream of neuron differentiation	IMP IMP: Inferred from mutant phenotype	7605629	MGI
acts upstream of or within neuron fate determination	IDA IDA: Inferred from direct assay	22726835	MGI
acts upstream of or within positive regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	15893304	MGI
acts upstream of or within positive regulation of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	15893304	MGI
acts upstream of or within positive regulation of neuron differentiation	IGI IGI: Inferred from genetic interaction	16314515	MGI
acts upstream of or within pyramidal neuron migration to cerebral cortex	IDA IDA: Inferred from direct assay	22726835	MGI
acts upstream of or within regulation of cell cycle	IDA IDA: Inferred from direct assay	22726835	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22726835	MGI
acts upstream of or within regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	12151532	MGI
acts upstream of or within regulation of neural precursor cell proliferation	IGI IGI: Inferred from genetic interaction	22516202	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	16314515	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

forkhead box protein G1

HNF-3/forkhead homolog, brain factor 1

forkhead-related protein FKHL1

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N3610	Coclaurine	Antagonist	98.97%	Unkown
HY-RS05051	FOXG1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Foxg1	NCBI	NCBI:2290

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