Foxd1 - forkhead box D1 Gene

Also Known as BF-2; Hfh10; FREAC4; Hfhbf2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15229

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including kidney development; luteinizing hormone secretion; and regulation of gene expression. Acts upstream of or within axon guidance; branching involved in ureteric bud morphogenesis; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; integumental system; metanephros; nervous system; and sensory organ. Orthologous to human FOXD1 (forkhead box D1). [provided by Alliance of Genome Resources, Apr 2022]

Foxd1 Products (1)

mRNA Protein Name
NM_008242.2 NP_032268.2 forkhead box protein D1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
13678594 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
13678594 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
13678594 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
13678594 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
15509772 MGI
acts upstream of or within branching involved in ureteric bud morphogenesis IDA
IDA: Inferred from direct assay
13678594 MGI
involved in canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
32868762 MGI
involved in dichotomous subdivision of terminal units involved in ureteric bud branching IMP
IMP: Inferred from mutant phenotype
15634693 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
8666231 MGI
involved in luteinizing hormone secretion IMP
IMP: Inferred from mutant phenotype
23284914 MGI
involved in metanephric capsule development IMP
IMP: Inferred from mutant phenotype
15634693 MGI
involved in metanephric capsule specification IMP
IMP: Inferred from mutant phenotype
15634693 MGI
involved in metanephric nephron development IMP
IMP: Inferred from mutant phenotype
15634693 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
15634693 MGI
involved in nephrogenic mesenchyme development IMP
IMP: Inferred from mutant phenotype
15634693 MGI
involved in pattern specification involved in metanephros development IMP
IMP: Inferred from mutant phenotype
15634693 MGI
involved in positive regulation of BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
15634693 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
15634693 MGI
involved in positive regulation of kidney development IMP
IMP: Inferred from mutant phenotype
15634693 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
13678594 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
13678594 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

forkhead box protein D1

  • FORKHEAD BOX PROTEIN D1 (FORKHEAD-RELATED PROTEIN FKHL8) (FORKHEAD-RELATED TRANSCRIPTION FACTOR 4) (FREAC-4)

  • FREAC-4

  • HFH-BF-2

  • HNF-3/forkhead homolog, brain factor 2

  • brain factor 2

  • forkhead-related protein FKHL8

  • forkhead-related transcription factor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05043 FOXD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19682 Foxd1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26175 Foxd1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Foxd1 NCBI NCBI:2297