Mnx1 - motor neuron and pancreas homeobox 1 Gene

Also Known as HB9; MNR2; Hlxb9

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15285

Summary

Predicted to enable sequence-specific double-stranded DNA binding activity. Acts upstream of or within several processes, including diaphragm development; endocrine pancreas development; and nervous system development. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; lung epithelium; and notochord. Human ortholog(s) of this gene implicated in Currarino syndrome. Orthologous to human MNX1 (motor neuron and pancreas homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Mnx1 Products (1)

mRNA Protein Name
NM_019944.2 NP_064328.2 motor neuron and pancreas homeobox protein 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell morphogenesis involved in neuron differentiation IMP
IMP: Inferred from mutant phenotype
10482234 MGI
acts upstream of or within central nervous system neuron differentiation IMP
IMP: Inferred from mutant phenotype
10482234 MGI
acts upstream of or within diaphragm development IMP
IMP: Inferred from mutant phenotype
10482234 MGI
acts upstream of or within dorsal/ventral neural tube patterning IDA
IDA: Inferred from direct assay
18590716 MGI
acts upstream of or within endocrine pancreas development IMP
IMP: Inferred from mutant phenotype
10471501 MGI
acts upstream of or within motor neuron axon guidance IMP
IMP: Inferred from mutant phenotype
10482234 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18539116 MGI
acts upstream of or within nerve development IMP
IMP: Inferred from mutant phenotype
11395002 MGI
acts upstream of or within neuron differentiation IMP
IMP: Inferred from mutant phenotype
11395002 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
10482234 MGI
acts upstream of or within neuron projection morphogenesis IMP
IMP: Inferred from mutant phenotype
10482234 MGI
acts upstream of or within pancreas development IMP
IMP: Inferred from mutant phenotype
10471501 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
10482234 MGI
acts upstream of or within respiratory system development IMP
IMP: Inferred from mutant phenotype
10482234 MGI
acts upstream of or within spinal cord motor neuron cell fate specification IMP
IMP: Inferred from mutant phenotype
10482234 MGI
involved in spinal cord motor neuron cell fate specification IMP
IMP: Inferred from mutant phenotype
18539116 MGI
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
18539116 MGI
located in nucleus IDA
IDA: Inferred from direct assay
17042795 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

motor neuron and pancreas homeobox protein 1

  • homeobox gene HB9

  • homeobox protein HB9

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08571 MNX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174579 Human MNX1 mRNA / Unkown
HY-RS20296 Mnx1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26804 Mnx1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mnx1 NCBI NCBI:3110