RASGEF1B - RasGEF domain family member 1B Gene

Also Known as GPIG4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 153020

About RASGEF1B

Cytogenetic location: 4q21.21 Genomic coordinates (GRCh38): 4:81,426,393-81,471,907 (from NCBI)

This gene has 13 transcripts (splice variants), 281 orthologues and 24 paralogues. Ubiquitous expression in skin (RPKM 10.2), bone marrow (RPKM 8.3) and 24 other tissues.

Summary

Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of catalytic activity and small GTPase mediated signal transduction. Predicted to be located in early endosome; late endosome; and midbody. [provided by Alliance of Genome Resources, Apr 2022]

RASGEF1B Products (3)

mRNA Protein Name
NM_001300735.2 NP_001287664.1 ras-GEF domain-containing family member 1B isoform 2
NM_001300736.2 NP_001287665.1 ras-GEF domain-containing family member 1B isoform 3
NM_152545.3 NP_689758.1 ras-GEF domain-containing family member 1B isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
19645719 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RASGEF1B Protein Structure

RasGEF_N

RasGEF_N: RasGEF N-terminal motif (39 - 135)

RasGEF

RasGEF: RasGEF domain (205 - 403)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 473 a.a.
Protein Preferred Names Protein Names

ras-GEF domain-containing family member 1B

  • GPI gamma-4

Related Diseases

Diseases Alias
Dystonia 24

  • DYT24

  • Cranio-Cervical Dystonia With Laryngeal And Upper-Limb Involvement

  • Dystonia-24

  • Dystonia, Type 24
Chromosome 4q21 Deletion Syndrome

  • 4q21 Microdeletion Syndrome

  • Monosomy 4q21

  • Del(4)(Q21)

  • Chromosome Deletion Syndrome 4q21
Malignant Hemangioma
Ileum Cancer

  • Ileal Neoplasm

  • Malignant Neoplasm Of Ileum

  • Ileal Cancer

  • Ileal Neoplasms
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11689 RASGEF1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RASGEF1B VGNC VGNC:45368
Felis catus RASGEF1B VGNC VGNC:64500
Macaca mulatta RASGEF1B VGNC VGNC:76532
Mus musculus RASGEF1B MGD MGI:2443755
Bos taurus RASGEF1B VGNC VGNC:33744
Rattus norvegicus RASGEF1B RGD RGD:1562220
Others RASGEF1B NCBI