Hmx2 - H6 homeobox 2 Gene

Also Known as Nkx5-2; Nkx-5.2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15372

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including inner ear morphogenesis; positive regulation of cell population proliferation; and positive regulation of mRNA splicing, via spliceosome. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system; gut; nervous system; sensory organ; and thymus. Orthologous to human HMX2 (H6 family homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Hmx2 Products (2)

mRNA Protein Name
NM_001368360.1 NP_001355289.1 homeobox protein HMX2
NM_145998.4 NP_666110.1 homeobox protein HMX2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within brain development IGI
IGI: Inferred from genetic interaction
15363417 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
11748138 MGI
acts upstream of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
11748138 MGI
acts upstream of or within inner ear morphogenesis IGI
IGI: Inferred from genetic interaction
15363417 MGI
acts upstream of or within inner ear morphogenesis IMP
IMP: Inferred from mutant phenotype
11748138 MGI
acts upstream of or within positive regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
11748138 MGI
acts upstream of or within positive regulation of mRNA splicing, via spliceosome IMP
IMP: Inferred from mutant phenotype
23636947 MGI
acts upstream of or within positive regulation of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
11748138 MGI
acts upstream of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
11748138 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein HMX2

  • H6 homeo box 2

  • NK-related homeobox

  • homeobox protein Nkx-5.2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06253 HMX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22201 Hmx2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28723 Hmx2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hmx2 NCBI NCBI:3167