Hmx3 - H6 homeobox 3 Gene

Mus musculus

Also known as Nkx5-1; Nkx5.1; Nkx-5.1

Gene ID: 15373 | Gene type: protein coding

About Hmx3

Summary

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in ear development. Acts upstream of or within several processes, including embryo implantation; maternal process involved in female pregnancy; and neuromuscular process controlling balance. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; female reproductive system; nervous system; and sensory organ. Orthologous to human HMX3 (H6 family homeobox 3). [provided by Alliance of Genome Resources, Apr 2022]

Hmx3 Products(1)

mRNA	Protein	Name
NM_008257.3	NP_032283.3	homeobox protein HMX3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10206974	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	10206974	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10206974	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within brain development	IGI IGI: Inferred from genetic interaction	15363417	MGI
involved in ear development	IMP IMP: Inferred from mutant phenotype	14695375	MGI
acts upstream of or within embryo implantation	IMP IMP: Inferred from mutant phenotype	9435283	MGI
acts upstream of or within inner ear morphogenesis	IGI IGI: Inferred from genetic interaction	15363417	MGI
acts upstream of or within inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	9435283	MGI
acts upstream of or within maternal process involved in female pregnancy	IMP IMP: Inferred from mutant phenotype	9435283	MGI
acts upstream of or within neuromuscular process controlling balance	IMP IMP: Inferred from mutant phenotype	9435283	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

homeobox protein HMX3

H6 homeo box 3	homeobox protein H6 family member 3
homeobox protein Nkx-5.1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06254	HMX3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hmx3	NCBI	NCBI:340784

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