Onecut1 - one cut domain, family member 1 Gene

Also Known as Oc1; Hnf6; OC-1; HNF-6; Hfh12; Hnf6b; D9Ertd423e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15379

Summary

Enables DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Acts upstream of or within several processes, including Notch signaling pathway; animal organ development; and negative regulation of transforming growth factor beta receptor signaling pathway. Located in nucleus. Is expressed in several structures, including central nervous system; gut; liver and biliary system; retina; and urinary system. Orthologous to human ONECUT1 (one cut homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Onecut1 Products (1)

mRNA Protein Name
NM_008262.3 NP_032288.1 hepatocyte nuclear factor 6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
16912278 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
10825208 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11944891 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
22780989 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell differentiation IMP
IMP: Inferred from mutant phenotype
12874218 MGI
acts upstream of or within Notch signaling pathway IDA
IDA: Inferred from direct assay
25446530 MGI
acts upstream of or within anatomical structure morphogenesis IMP
IMP: Inferred from mutant phenotype
16103213 MGI
acts upstream of or within cell fate commitment IGI
IGI: Inferred from genetic interaction
16103213 MGI
acts upstream of cell migration IGI
IGI: Inferred from genetic interaction
17936262 MGI
acts upstream of or within cilium assembly IMP
IMP: Inferred from mutant phenotype
16472605 MGI
acts upstream of or within endocrine pancreas development IGI
IGI: Inferred from genetic interaction
17400205 MGI
acts upstream of or within endoderm development IMP
IMP: Inferred from mutant phenotype
10825208 MGI
acts upstream of or within enteroendocrine cell differentiation IMP
IMP: Inferred from mutant phenotype
10825208 MGI
acts upstream of or within epithelial cell development IMP
IMP: Inferred from mutant phenotype
16472605 MGI
acts upstream of or within glucose metabolic process IMP
IMP: Inferred from mutant phenotype
10825208 MGI
acts upstream of or within liver development IGI
IGI: Inferred from genetic interaction
17936262 MGI
acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway IGI
IGI: Inferred from genetic interaction
16103213 MGI
acts upstream of or within pancreas development IGI
IGI: Inferred from genetic interaction
17400205 MGI
acts upstream of or within pancreas development IMP
IMP: Inferred from mutant phenotype
17400205 MGI
acts upstream of or within pancreatic A cell differentiation IMP
IMP: Inferred from mutant phenotype
10825208 MGI
acts upstream of or within pancreatic D cell differentiation IMP
IMP: Inferred from mutant phenotype
10825208 MGI
acts upstream of or within positive regulation of cell migration IGI
IGI: Inferred from genetic interaction
17936262 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17261592 MGI
acts upstream of or within regulation of cell-matrix adhesion IGI
IGI: Inferred from genetic interaction
17936262 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
12874218 MGI
acts upstream of or within spleen development IMP
IMP: Inferred from mutant phenotype
12874218 MGI
acts upstream of transforming growth factor beta receptor signaling pathway IGI
IGI: Inferred from genetic interaction
16103213 MGI
acts upstream of or within type B pancreatic cell differentiation IMP
IMP: Inferred from mutant phenotype
10825208 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
15548585 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hepatocyte nuclear factor 6

  • HNF-3/forkhead homolog 12

  • hepatic nuclear factor 6

  • one cut homeobox 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09785 ONECUT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Onecut1 NCBI NCBI:3175