Onecut1 - one cut domain, family member 1 Gene

Mus musculus

Also known as Oc1; Hnf6; OC-1; HNF-6; Hfh12; Hnf6b; D9Ertd423e

Gene ID: 15379 | Gene type: protein coding

About Onecut1

Summary

Enables DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Acts upstream of or within several processes, including Notch signaling pathway; animal organ development; and negative regulation of transforming growth factor beta receptor signaling pathway. Located in nucleus. Is expressed in several structures, including central nervous system; gut; liver and biliary system; retina; and urinary system. Orthologous to human ONECUT1 (one cut homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Onecut1 Products(1)

mRNA	Protein	Name
NM_008262.3	NP_032288.1	hepatocyte nuclear factor 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	16912278	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	10825208	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11944891	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	22780989	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell differentiation	IMP IMP: Inferred from mutant phenotype	12874218	MGI
acts upstream of or within Notch signaling pathway	IDA IDA: Inferred from direct assay	25446530	MGI
acts upstream of or within anatomical structure morphogenesis	IMP IMP: Inferred from mutant phenotype	16103213	MGI
acts upstream of or within cell fate commitment	IGI IGI: Inferred from genetic interaction	16103213	MGI
acts upstream of cell migration	IGI IGI: Inferred from genetic interaction	17936262	MGI
acts upstream of or within cilium assembly	IMP IMP: Inferred from mutant phenotype	16472605	MGI
acts upstream of or within endocrine pancreas development	IGI IGI: Inferred from genetic interaction	17400205	MGI
acts upstream of or within endoderm development	IMP IMP: Inferred from mutant phenotype	10825208	MGI
acts upstream of or within enteroendocrine cell differentiation	IMP IMP: Inferred from mutant phenotype	10825208	MGI
acts upstream of or within epithelial cell development	IMP IMP: Inferred from mutant phenotype	16472605	MGI
acts upstream of or within glucose metabolic process	IMP IMP: Inferred from mutant phenotype	10825208	MGI
acts upstream of or within liver development	IGI IGI: Inferred from genetic interaction	17936262	MGI
acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway	IGI IGI: Inferred from genetic interaction	16103213	MGI
acts upstream of or within pancreas development	IGI IGI: Inferred from genetic interaction	17400205	MGI
acts upstream of or within pancreas development	IMP IMP: Inferred from mutant phenotype	17400205	MGI
acts upstream of or within pancreatic A cell differentiation	IMP IMP: Inferred from mutant phenotype	10825208	MGI
acts upstream of or within pancreatic D cell differentiation	IMP IMP: Inferred from mutant phenotype	10825208	MGI
acts upstream of or within positive regulation of cell migration	IGI IGI: Inferred from genetic interaction	17936262	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17261592	MGI
acts upstream of or within regulation of cell-matrix adhesion	IGI IGI: Inferred from genetic interaction	17936262	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12874218	MGI
acts upstream of or within spleen development	IMP IMP: Inferred from mutant phenotype	12874218	MGI
acts upstream of transforming growth factor beta receptor signaling pathway	IGI IGI: Inferred from genetic interaction	16103213	MGI
acts upstream of or within type B pancreatic cell differentiation	IMP IMP: Inferred from mutant phenotype	10825208	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	15548585	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

hepatocyte nuclear factor 6

HNF-3/forkhead homolog 12	hepatic nuclear factor 6
one cut homeobox 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09785	ONECUT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Onecut1	NCBI	NCBI:3175

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