Hoxb13 - homeobox B13 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15408

Summary

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and methyl-CpG binding activity. Acts upstream of or within epithelial cell maturation involved in prostate gland development; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; and regulation of growth. Part of transcription regulator complex. Is expressed in several structures, including genitourinary system; gut; lung; spinal cord; and tail. Human ortholog(s) of this gene implicated in ductal carcinoma in situ and renal cell carcinoma. Orthologous to human HOXB13 (homeobox B13). [provided by Alliance of Genome Resources, Apr 2022]

Hoxb13 Products (1)

mRNA Protein Name
NM_008267.4 NP_032293.1 homeobox protein Hox-B13

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9343407 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within epithelial cell maturation involved in prostate gland development IMP
IMP: Inferred from mutant phenotype
12668621 MGI
acts upstream of or within morphogenesis of an epithelium IMP
IMP: Inferred from mutant phenotype
12668621 MGI
acts upstream of or within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IGI
IGI: Inferred from genetic interaction
12620974 MGI
acts upstream of or within regulation of growth IMP
IMP: Inferred from mutant phenotype
12679105 MGI
Cellular Component GO Annotation Evidence References Source
part of transcription regulator complex IDA
IDA: Inferred from direct assay
9343407 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein Hox-B13

  • homeo box B13

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125051 SG3-179 Inhibitor / Unkown
HY-RS06305 HOXB13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hoxb13 NCBI NCBI:10481