Hoxd13 - homeobox D13 Gene

Mus musculus

Also known as spdh; Hox-4.8

Gene ID: 15433 | Gene type: protein coding

About Hoxd13

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Acts upstream of or within several processes, including male genitalia development; morphogenesis of an epithelium; and regulation of branching involved in prostate gland morphogenesis. Located in nucleus. Is expressed in several structures, including genitourinary system; hindgut; limb; limb bud; and tail. Used to study synpolydactyly. Human ortholog(s) of this gene implicated in brachydactyly-syndactyly syndrome; clubfoot; cryptorchidism; and dysostosis (multiple). Orthologous to human HOXD13 (homeobox D13). [provided by Alliance of Genome Resources, Apr 2022]

Hoxd13 Products(1)

mRNA	Protein	Name
NM_008275.4	NP_032301.2	homeobox protein Hox-D13

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	19168674	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	16314414	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	16314414	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16314414	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	16672333	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	27706137	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	8106170	MGI
acts upstream of or within branch elongation of an epithelium	IMP IMP: Inferred from mutant phenotype	9097018	MGI
acts upstream of or within embryonic digit morphogenesis	IGI IGI: Inferred from genetic interaction	8900279	MGI
acts upstream of or within embryonic limb morphogenesis	IMP IMP: Inferred from mutant phenotype	11850178	MGI
acts upstream of or within gland morphogenesis	IMP IMP: Inferred from mutant phenotype	9097018	MGI
acts upstream of or within limb morphogenesis	IGI IGI: Inferred from genetic interaction	8978698	MGI
acts upstream of or within limb morphogenesis	IMP IMP: Inferred from mutant phenotype	11543619	MGI
acts upstream of or within male genitalia development	IMP IMP: Inferred from mutant phenotype	8106170	MGI
acts upstream of or within morphogenesis of an epithelial fold	IMP IMP: Inferred from mutant phenotype	9097018	MGI
acts upstream of or within pattern specification process	IGI IGI: Inferred from genetic interaction	8900279	MGI
acts upstream of or within pattern specification process	IMP IMP: Inferred from mutant phenotype	8106170	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16314414	MGI
acts upstream of or within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	IGI IGI: Inferred from genetic interaction	12668621	MGI
acts upstream of or within regulation of branching involved in prostate gland morphogenesis	IMP IMP: Inferred from mutant phenotype	9097018	MGI
acts upstream of or within regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	11850178	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	8106170	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16314414	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	15617687	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

homeobox protein Hox-D13

homeo box D13

homeobox protein Hox-4.8

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06326	HOXD13 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hoxd13	NCBI	NCBI:3239

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