Hoxd13 - homeobox D13 Gene

Also Known as spdh; Hox-4.8

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15433

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Acts upstream of or within several processes, including male genitalia development; morphogenesis of an epithelium; and regulation of branching involved in prostate gland morphogenesis. Located in nucleus. Is expressed in several structures, including genitourinary system; hindgut; limb; limb bud; and tail. Used to study synpolydactyly. Human ortholog(s) of this gene implicated in brachydactyly-syndactyly syndrome; clubfoot; cryptorchidism; and dysostosis (multiple). Orthologous to human HOXD13 (homeobox D13). [provided by Alliance of Genome Resources, Apr 2022]

Hoxd13 Products (1)

mRNA Protein Name
NM_008275.4 NP_032301.2 homeobox protein Hox-D13

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
19168674 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
16314414 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
16314414 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16314414 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
16672333 MGI
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
27706137 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
8106170 MGI
acts upstream of or within branch elongation of an epithelium IMP
IMP: Inferred from mutant phenotype
9097018 MGI
acts upstream of or within embryonic digit morphogenesis IGI
IGI: Inferred from genetic interaction
8900279 MGI
acts upstream of or within embryonic limb morphogenesis IMP
IMP: Inferred from mutant phenotype
11850178 MGI
acts upstream of or within gland morphogenesis IMP
IMP: Inferred from mutant phenotype
9097018 MGI
acts upstream of or within limb morphogenesis IGI
IGI: Inferred from genetic interaction
8978698 MGI
acts upstream of or within limb morphogenesis IMP
IMP: Inferred from mutant phenotype
11543619 MGI
acts upstream of or within male genitalia development IMP
IMP: Inferred from mutant phenotype
8106170 MGI
acts upstream of or within morphogenesis of an epithelial fold IMP
IMP: Inferred from mutant phenotype
9097018 MGI
acts upstream of or within pattern specification process IGI
IGI: Inferred from genetic interaction
8900279 MGI
acts upstream of or within pattern specification process IMP
IMP: Inferred from mutant phenotype
8106170 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16314414 MGI
acts upstream of or within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IGI
IGI: Inferred from genetic interaction
12668621 MGI
acts upstream of or within regulation of branching involved in prostate gland morphogenesis IMP
IMP: Inferred from mutant phenotype
9097018 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
11850178 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
8106170 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16314414 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
15617687 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein Hox-D13

  • homeo box D13

  • homeobox protein Hox-4.8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06326 HOXD13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hoxd13 NCBI NCBI:3239