Lipc - lipase, hepatic Gene

Also Known as HL; Hpl

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15450

Summary

Enables Lipase activity. Acts upstream of or within Cholesterol homeostasis; Cholesterol metabolic process; and Cholesterol transport. Located in extracellular space. Is expressed in liver and liver lobe. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; familial combined hyperlipidemia; glucose metabolism disease (multiple); obesity; and peripheral vascular disease. Orthologous to human LIPC (Lipase C, hepatic type). [provided by Alliance of Genome Resources, Apr 2022]

Lipc Products (6)

mRNA Protein Name
NM_001324472.1 NP_001311401.1 hepatic triacylglycerol lipase isoform 1 precursor
NM_001324473.1 NP_001311402.1 hepatic triacylglycerol lipase isoform 2
NM_001411787.1 NP_001398716.1 hepatic triacylglycerol lipase isoform 1 precursor
NM_001411788.1 NP_001398717.1 hepatic triacylglycerol lipase isoform 3 precursor
NM_001411789.1 NP_001398718.1 hepatic triacylglycerol lipase isoform 4 precursor
NM_008280.2 NP_032306.2 hepatic triacylglycerol lipase isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables lipase activity IDA
IDA: Inferred from direct assay
12975454 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cholesterol homeostasis IGI
IGI: Inferred from genetic interaction
10357838 MGI
acts upstream of or within cholesterol metabolic process IGI
IGI: Inferred from genetic interaction
10357838 MGI
acts upstream of or within cholesterol transport IMP
IMP: Inferred from mutant phenotype
8798380 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
15995171 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hepatic triacylglycerol lipase

  • hepatic lipase

  • lipase member C

  • lysophospholipase

  • phospholipase A1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07686 LIPC Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lipc NCBI NCBI:3990