2. Gene
  3. Hsd17b3 - hydroxysteroid (17-beta) dehydrogenase 3 Gene

Hsd17b3 - hydroxysteroid (17-beta) dehydrogenase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 15487 | Gene type: protein coding

About Hsd17b3

Summary

Predicted to enable estradiol 17-beta-dehydrogenase activity; testosterone 17-beta-dehydrogenase (NADP+) activity; and testosterone dehydrogenase (NAD+) activity. Predicted to be involved in steroid biosynthetic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in endoplasmic reticulum. Is expressed in testis. Used to study pseudohermaphroditism. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency and disorder of sexual development. Orthologous to human HSD17B3 (hydroxysteroid 17-beta dehydrogenase 3). [provided by Alliance of Genome Resources, Apr 2022]

Hsd17b3 Products(1)

mRNA Protein Name
NM_008291.3 NP_032317.2 17-beta-hydroxysteroid dehydrogenase type 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables testosterone dehydrogenase [NAD(P)+] activity IMP
IMP: Inferred from mutant phenotype
32557858 MGI
Biological Process GO Annotation Evidence Reference Source
involved in androgen biosynthetic process IMP
IMP: Inferred from mutant phenotype
32557858 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in endoplasmic reticulum IDA
IDA: Inferred from direct assay
23183177 MGI
is active in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
23183177 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

17-beta-hydroxysteroid dehydrogenase type 3

testosterone 17-beta-dehydrogenase 3

17(beta)HSD type 3

17-beta-HSD 3

estradiol 17-beta-dehydrogenase 2

testicular 17-beta-hydroxysteroid dehydrogenase

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06396 HSD17B3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hsd17b3 NCBI NCBI:3293