Hsd17b7 - hydroxysteroid (17-beta) dehydrogenase 7 Gene

Also Known as ERG27

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15490

Summary

Enables 3-keto sterol reductase activity; 5alpha-androstane-3beta,17beta-diol dehydrogenase activity; and estradiol 17-beta-dehydrogenase activity. Involved in animal organ development and cellular hormone metabolic process. Acts upstream of or within several processes, including Cholesterol biosynthetic process; embryonic skeletal system development; and nervous system development. Located in endoplasmic reticulum membrane. Is expressed in several structures, including autopod; branchial arch; eye; nervous system; and spleen primordium. Orthologous to human HSD17B7 (hydroxysteroid 17-beta dehydrogenase 7). [provided by Alliance of Genome Resources, Apr 2022]

Hsd17b7 Products (1)

mRNA Protein Name
NM_010476.3 NP_034606.3 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3-keto sterol reductase activity IDA
IDA: Inferred from direct assay
12829805 MGI
enables 5alpha-androstane-3beta,17beta-diol dehydrogenase activity IDA
IDA: Inferred from direct assay
12732193 MGI
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IDA
IDA: Inferred from direct assay
9658408 MGI
Biological Process GO Annotation Evidence References Source
involved in androgen metabolic process IDA
IDA: Inferred from direct assay
12732193 MGI
involved in brain development IMP
IMP: Inferred from mutant phenotype
18669642 MGI
acts upstream of or within cell differentiation IMP
IMP: Inferred from mutant phenotype
21515572 MGI
acts upstream of or within cholesterol biosynthetic process IDA
IDA: Inferred from direct assay
12829805 MGI
involved in embryonic organ development IMP
IMP: Inferred from mutant phenotype
18669642 MGI
acts upstream of or within embryonic skeletal system development IMP
IMP: Inferred from mutant phenotype
21515572 MGI
involved in estrogen biosynthetic process IDA
IDA: Inferred from direct assay
9658408 MGI
acts upstream of or within nervous system development IMP
IMP: Inferred from mutant phenotype
21515572 MGI
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
12829805 MGI
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
12829805 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7

  • 17-beta-HSD 7

  • 17-beta-hydroxysteroid dehydrogenase 7

  • 3-keto-steroid reductase

  • dihydrotestosterone oxidoreductase

  • estradiol 17-beta-dehydrogenase 7

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06399 HSD17B7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W749520 Zymosterone / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hsd17b7 NCBI NCBI:51478