Hspg2 - perlecan (heparan sulfate proteoglycan 2) Gene

Also Known as Pcn; Plc; per; HSPG

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15530

Summary

Enables protease binding activity. Involved in receptor-mediated endocytosis. Acts upstream of or within several processes, including animal organ development; extracellular matrix organization; and skeletal system development. Located in basement membrane. Is expressed in several structures, including alimentary system; cardiovascular system; early conceptus; genitourinary system; and nervous system. Used to study Schwartz-Jampel syndrome 1; Silverman-Handmaker type dyssegmental dysplasia; dextro-looped transposition of the great arteries; and thanatophoric dysplasia. Human ortholog(s) of this gene implicated in Schwartz-Jampel syndrome 1; Silverman-Handmaker type dyssegmental dysplasia; and osteochondrodysplasia. Orthologous to human HSPG2 (heparan sulfate proteoglycan 2). [provided by Alliance of Genome Resources, Apr 2022]

Hspg2 Products (1)

mRNA Protein Name
NM_008305.3 NP_032331.2 basement membrane-specific heparan sulfate proteoglycan core protein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protease binding IPI
IPI: Inferred from physical interaction
22952693 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12243745 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
10579729 MGI
acts upstream of or within cardiac muscle tissue development IMP
IMP: Inferred from mutant phenotype
10579729 MGI
acts upstream of or within cartilage development involved in endochondral bone morphogenesis IMP
IMP: Inferred from mutant phenotype
10545953 MGI
acts upstream of or within chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
10545953 MGI
acts upstream of or within embryonic skeletal system morphogenesis IMP
IMP: Inferred from mutant phenotype
10579729 MGI
acts upstream of or within endochondral ossification IMP
IMP: Inferred from mutant phenotype
10579729 MGI
acts upstream of or within extracellular matrix organization IMP
IMP: Inferred from mutant phenotype
10579729 MGI
acts upstream of or within protein localization IMP
IMP: Inferred from mutant phenotype
11802174 MGI
involved in receptor-mediated endocytosis IGI
IGI: Inferred from genetic interaction
21289173 MGI
involved in receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
21289173 MGI
Cellular Component GO Annotation Evidence References Source
located in basement membrane IDA
IDA: Inferred from direct assay
7670489 MGI
located in extracellular matrix IDA
IDA: Inferred from direct assay
10579729 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

basement membrane-specific heparan sulfate proteoglycan core protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06449 HSPG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19691 Hspg2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26186 Hspg2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hspg2 NCBI NCBI:3339