Hyal1 - hyaluronoglucosaminidase 1 Gene

Also Known as Fus2; Hya1; Nat6; Hyal-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15586

Summary

Predicted to enable hyaluronan synthase activity and hyalurononglucosaminidase activity. Involved in response to virus. Acts upstream of or within embryonic skeletal joint morphogenesis. Predicted to be located in extracellular space; hyaluranon cable; and lysosome. Predicted to be active in cytoplasmic vesicle. Is expressed in liver and metanephros. Used to study mucopolysaccharidosis IX. Human ortholog(s) of this gene implicated in mucopolysaccharidosis and mucopolysaccharidosis IX. Orthologous to human HYAL1 (hyaluronidase 1). [provided by Alliance of Genome Resources, Apr 2022]

Hyal1 Products (2)

mRNA Protein Name
NM_001331161.2 NP_001318090.2 hyaluronidase-1 isoform 2 precursor
NM_008317.6 NP_032343.3 hyaluronidase-1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chondroitin hydrolase activity IMP
IMP: Inferred from mutant phenotype
22451654 MGI
enables hyalurononglucosaminidase activity IMP
IMP: Inferred from mutant phenotype
26887442 MGI
NOT enables virus receptor activity IDA
IDA: Inferred from direct assay
11296287 MGI
Biological Process GO Annotation Evidence References Source
involved in chondroitin sulfate catabolic process IMP
IMP: Inferred from mutant phenotype
22451654 MGI
acts upstream of or within embryonic skeletal joint morphogenesis IMP
IMP: Inferred from mutant phenotype
18772348 MGI
involved in hyaluronan catabolic process IMP
IMP: Inferred from mutant phenotype
22451654 MGI
involved in response to virus IDA
IDA: Inferred from direct assay
11296287 MGI
Cellular Component GO Annotation Evidence References Source
is active in lysosome IDA
IDA: Inferred from direct assay
24667601 MGI
is active in lysosome IMP
IMP: Inferred from mutant phenotype
22451654 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hyaluronidase-1

  • N-acetyltransferase 6

  • Protein fus-2

  • Protein fusion-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06495 HYAL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13628 SPAM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19442 Hyal1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25934 Hyal1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hyal1 NCBI NCBI:3373