CYP2C18 - cytochrome P450 family 2 subfamily C member 18 Gene

Also Known as CPCI; CYP2C; CYP2C17; P450IIC17; P450-6B/29C

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1562

About CYP2C18

Cytogenetic location: 10q23.33 Genomic coordinates (GRCh38): 10:94,683,729-94,736,190 (from NCBI)

This gene has 2 transcripts (splice variants), 49 orthologues and 15 paralogues. Biased expression in liver (RPKM 50.3), duodenum (RPKM 49.6) and 5 other tissues.

Summary

This gene encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of Cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

CYP2C18 Products (2)

mRNA	Protein	Name
NM_000772.3	NP_000763.1	cytochrome P450 2C18 isoform 1 precursor
NM_001128925.2	NP_001122397.1	cytochrome P450 2C18 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables retinoic acid 4-hydroxylase activity	IDA IDA: Inferred from direct assay	11093772	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in retinoic acid metabolic process	IDA IDA: Inferred from direct assay	11093772	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYP2C18 Protein Structure

p450

0
100
200
300
400
490 a.a.

Protein Preferred Names	Protein Names
cytochrome P450 2C18	(S)-mephenytoin hydroxylase associated cytochrome P450

Related Diseases

Diseases	Alias
Danubian Endemic Familial Nephropathy	Balkan Nephropathy Balkan Endemic Nephropathy Nephropathia Epidemica Defn Ben Aristolochic Acid Nephropathy Aan Endemic Nephropathy Balkan Balkan Nephritis
Coumarin Resistance	Warfarin Resistance Warfarin Sensitivity Coumadin Sensitivity Warfarin Response Poor Metabolism Of Coumarin Coumarin, Poor Metabolism Of CMRES
Hemoglobin D Disease	Hb-D Disease Punjab Disease Los Angeles Disease Hb D Los Angeles Disease Hb D Punjab Disease
Plasmodium Ovale Malaria	Ovale Malaria Malariaby Plasmodium Ovale
Korean Hemorrhagic Fever	Hemorrhagic Fever With Renal Syndrome
Hemoglobin C Disease	Hb C Disease Hemoglobin C Hb-C Disease
Enterocele	Vaginal Enterocele Hernia Hernias
Prolapse Of Female Genital Organ
Median Neuropathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03457	CYP2C18 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CYP2C18	RGD	RGD:1563697