CYP2F1 - cytochrome P450 family 2 subfamily F member 1 Gene

Also Known as C2F1; CYP2F; CYPIIF1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1572

About CYP2F1

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:41,114,432-41,128,381 (from NCBI)

This gene has 6 transcripts (splice variants), 78 orthologues and 15 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of Cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]

CYP2F1 Products (1)

mRNA Protein Name
NM_000774.5 NP_000765.2 cytochrome P450 2F1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IDA
IDA: Inferred from direct assay
10383923 GOA
Biological Process GO Annotation Evidence References Source
involved in naphthalene catabolic process IDA
IDA: Inferred from direct assay
10383923 GOA
Cellular Component GO Annotation Evidence References Source
located in intracellular membrane-bounded organelle IDA
IDA: Inferred from direct assay
10383923 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYP2F1 Protein Structure

p450

p450: Cytochrome P450 (31 - 488)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 491 a.a.
Protein Preferred Names Protein Names

cytochrome P450 2F1

  • cytochrome P450, family 2, subfamily F, polypeptide 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03464 CYP2F1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CYP2F1 VGNC VGNC:103640
Felis catus CYP2F1 VGNC VGNC:103485
Canis familiaris CYP2F1 VGNC VGNC:50386
Rattus norvegicus CYP2F1 RGD RGD:2476
Bos taurus CYP2F1 VGNC VGNC:110257
Mus musculus CYP2F1 MGD MGI:88608
Others CYP2F1 NCBI