NKX6-3 - NK6 homeobox 3 Gene

Also Known as NKX6.3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 157848

About NKX6-3

Cytogenetic location: 8p11.21 Genomic coordinates (GRCh38): 8:41,645,177-41,650,817 (from NCBI)

This gene has 2 transcripts (splice variants), 204 orthologues and 13 paralogues. Biased expression in stomach (RPKM 15.7) and duodenum (RPKM 4.5).

Summary

The NKX family of homeodomain proteins controls numerous developmental processes. Members of the NKX6 subfamily, including NKX6-3, are involved in development of the central nervous system (CNS), gastrointestinal tract, and pancreas (Alanentalo et al., 2006 [PubMed 16326147]).[supplied by OMIM, Mar 2008]

NKX6-3 Products (2)

mRNA Protein Name
NM_001364841.2 NP_001351770.1 homeobox protein Nkx-6.3 isoform 1
NM_152568.3 NP_689781.1 homeobox protein Nkx-6.3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
26314965 GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
26314965 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
26314965 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
26314965 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
26314965 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NKX6-3 Protein Structure

Homeobox

Homeobox: Homeobox domain (140 - 196)

  • 0
  • 100
  • 200
  • 265 a.a.
Protein Preferred Names Protein Names

homeobox protein Nkx-6.3

  • NK6 transcription factor related, locus 3

Related Diseases

Diseases Alias
Duodenal Gastrinoma

  • Duodenal G-Cell Gastrin Producing Tumor

  • Gastrinoma Of Duodenum

  • Malignant Duodenal Gastrinoma

  • Duodenal Gastrin-Producing Neuroendocrine Tumor
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09337 NKX6-3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NKX6-3 RGD RGD:1597780
Felis catus NKX6-3 VGNC VGNC:63819
Bos taurus NKX6-3 VGNC VGNC:32108
Mus musculus NKX6-3 MGD MGI:1921811
Others NKX6-3 NCBI