Irgm1 - immunity-related GTPase family M member 1 Gene

Mus musculus

Also known as Ifi1; Irgm; Iigp3; Iipg3; Ifggd3

Gene ID: 15944 | Gene type: protein coding

About Irgm1

Summary

Predicted to enable several functions, including GTPase activity; protein domain specific binding activity; and protein serine/threonine kinase activator activity. Involved in several processes, including positive regulation by symbiont of host autophagy; positive regulation of autophagosome maturation; and positive regulation of interferon-gamma-mediated signaling pathway. Acts upstream of or within cellular response to interferon-gamma and response to bacterium. Located in autolysosome; late endosome; and phagocytic vesicle. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Orthologous to human IRGM (immunity related GTPase M). [provided by Alliance of Genome Resources, Apr 2022]

Irgm1 Products(2)

mRNA	Protein	Name
NM_001355757.1	NP_001342686.1	immunity-related GTPase family M protein 1 isoform 2
NM_008326.2	NP_032352.1	immunity-related GTPase family M protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activity	IDA IDA: Inferred from direct assay	19620982	MGI
enables cardiolipin binding	IDA IDA: Inferred from direct assay	19620982	MGI
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA IDA: Inferred from direct assay	19620982	MGI
enables phosphatidylinositol-3,4-bisphosphate binding	IDA IDA: Inferred from direct assay	19620982	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in autophagosome assembly	IDA IDA: Inferred from direct assay	16888103	MGI
involved in autophagosome maturation	IDA IDA: Inferred from direct assay	21757726	MGI
acts upstream of or within cellular response to type II interferon	IDA IDA: Inferred from direct assay	19144319	MGI
acts upstream of or within defense response	IMP IMP: Inferred from mutant phenotype	11457893	MGI
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	19620982	MGI
involved in defense response to bacterium	IMP IMP: Inferred from mutant phenotype	16888103	MGI
involved in innate immune response	IDA IDA: Inferred from direct assay	19620982	MGI
involved in negative regulation of NLRP3 inflammasome complex assembly	IDA IDA: Inferred from direct assay	30612879	MGI
involved in negative regulation of defense response to virus	IMP IMP: Inferred from mutant phenotype	34467632	MGI
involved in negative regulation of hematopoietic stem cell proliferation	IMP IMP: Inferred from mutant phenotype	21633090	MGI
involved in negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	33510463	MGI
involved in negative regulation of type I interferon production	IMP IMP: Inferred from mutant phenotype	21633090	MGI
involved in negative regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	18806793	MGI
involved in positive regulation of CD4-positive, alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	18806793	MGI
involved in positive regulation of autophagosome maturation	IDA IDA: Inferred from direct assay	16888103	MGI
involved in positive regulation of autophagy	IDA IDA: Inferred from direct assay	19620982	MGI
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	16888103	MGI
involved in positive regulation of macrophage activation	IMP IMP: Inferred from mutant phenotype	27439214	MGI
involved in positive regulation of mitophagy	IMP IMP: Inferred from mutant phenotype	33510463	MGI
involved in positive regulation of type II interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	16888103	MGI
involved in regulation of mitochondrial fission	IDA IDA: Inferred from direct assay	24751652	MGI
acts upstream of or within response to bacterium	IEP IEP: Inferred from expression pattern	23012479	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Golgi membrane	IDA IDA: Inferred from direct assay	24751652	MGI
located in autolysosome	IDA IDA: Inferred from direct assay	16888103	MGI
located in autophagosome	IDA IDA: Inferred from direct assay	16888103	MGI
located in late endosome	IDA IDA: Inferred from direct assay	16888103	MGI
is active in lysosomal membrane	IDA IDA: Inferred from direct assay	27098192	MGI
located in lysosome	IDA IDA: Inferred from direct assay	20072621	MGI
is active in mitochondrial membrane	IDA IDA: Inferred from direct assay	24751652	MGI
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	19144319	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

immunity-related GTPase family M protein 1

LPS-stimulated RAW 264.7 macrophage protein 47	immunity related GTPase m1
interferon-gamma-inducible GTPase Ifggd3 protein	interferon-inducible protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06915	IRGM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Name
Email *

	Sorry, but the email address you supplied was invalid.