Irgm1 - immunity-related GTPase family M member 1 Gene

Also Known as Ifi1; Irgm; Iigp3; Iipg3; Ifggd3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15944

Summary

Predicted to enable several functions, including GTPase activity; protein domain specific binding activity; and protein serine/threonine kinase activator activity. Involved in several processes, including positive regulation by symbiont of host autophagy; positive regulation of autophagosome maturation; and positive regulation of interferon-gamma-mediated signaling pathway. Acts upstream of or within cellular response to interferon-gamma and response to bacterium. Located in autolysosome; late endosome; and phagocytic vesicle. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Orthologous to human IRGM (immunity related GTPase M). [provided by Alliance of Genome Resources, Apr 2022]

Irgm1 Products (2)

mRNA Protein Name
NM_001355757.1 NP_001342686.1 immunity-related GTPase family M protein 1 isoform 2
NM_008326.2 NP_032352.1 immunity-related GTPase family M protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activity IDA
IDA: Inferred from direct assay
19620982 MGI
enables cardiolipin binding IDA
IDA: Inferred from direct assay
19620982 MGI
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
IDA: Inferred from direct assay
19620982 MGI
enables phosphatidylinositol-3,4-bisphosphate binding IDA
IDA: Inferred from direct assay
19620982 MGI
Biological Process GO Annotation Evidence References Source
involved in autophagosome assembly IDA
IDA: Inferred from direct assay
16888103 MGI
involved in autophagosome maturation IDA
IDA: Inferred from direct assay
21757726 MGI
acts upstream of or within cellular response to type II interferon IDA
IDA: Inferred from direct assay
19144319 MGI
acts upstream of or within defense response IMP
IMP: Inferred from mutant phenotype
11457893 MGI
involved in defense response to bacterium IDA
IDA: Inferred from direct assay
19620982 MGI
involved in defense response to bacterium IMP
IMP: Inferred from mutant phenotype
16888103 MGI
involved in innate immune response IDA
IDA: Inferred from direct assay
19620982 MGI
involved in negative regulation of NLRP3 inflammasome complex assembly IDA
IDA: Inferred from direct assay
30612879 MGI
involved in negative regulation of defense response to virus IMP
IMP: Inferred from mutant phenotype
34467632 MGI
involved in negative regulation of hematopoietic stem cell proliferation IMP
IMP: Inferred from mutant phenotype
21633090 MGI
involved in negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
33510463 MGI
involved in negative regulation of type I interferon production IMP
IMP: Inferred from mutant phenotype
21633090 MGI
involved in negative regulation of type II interferon production IMP
IMP: Inferred from mutant phenotype
18806793 MGI
involved in positive regulation of CD4-positive, alpha-beta T cell proliferation IMP
IMP: Inferred from mutant phenotype
18806793 MGI
involved in positive regulation of autophagosome maturation IDA
IDA: Inferred from direct assay
16888103 MGI
involved in positive regulation of autophagy IDA
IDA: Inferred from direct assay
19620982 MGI
involved in positive regulation of autophagy IMP
IMP: Inferred from mutant phenotype
16888103 MGI
involved in positive regulation of macrophage activation IMP
IMP: Inferred from mutant phenotype
27439214 MGI
involved in positive regulation of mitophagy IMP
IMP: Inferred from mutant phenotype
33510463 MGI
involved in positive regulation of type II interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
16888103 MGI
involved in regulation of mitochondrial fission IDA
IDA: Inferred from direct assay
24751652 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
Cellular Component GO Annotation Evidence References Source
is active in Golgi membrane IDA
IDA: Inferred from direct assay
24751652 MGI
located in autolysosome IDA
IDA: Inferred from direct assay
16888103 MGI
located in autophagosome IDA
IDA: Inferred from direct assay
16888103 MGI
located in late endosome IDA
IDA: Inferred from direct assay
16888103 MGI
is active in lysosomal membrane IDA
IDA: Inferred from direct assay
27098192 MGI
located in lysosome IDA
IDA: Inferred from direct assay
20072621 MGI
is active in mitochondrial membrane IDA
IDA: Inferred from direct assay
24751652 MGI
located in phagocytic vesicle IDA
IDA: Inferred from direct assay
19144319 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

immunity-related GTPase family M protein 1

  • LPS-stimulated RAW 264.7 macrophage protein 47

  • immunity related GTPase m1

  • interferon-gamma-inducible GTPase Ifggd3 protein

  • interferon-inducible protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06915 IRGM Human Pre-designed siRNA Set A Pre-designed Set / Unkown