DGKH - diacylglycerol kinase eta Gene

Also Known as DGKeta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 160851

About DGKH

Cytogenetic location: 13q14.11 Genomic coordinates (GRCh38): 13:42,040,070-42,256,584 (from NCBI)

This gene has 10 transcripts (splice variants), 220 orthologues and 9 paralogues. Ubiquitous expression in endometrium (RPKM 2.6), placenta (RPKM 1.9) and 24 other tissues.

Summary

This gene encodes a member of the diacylglycerol kinase (DGK) enzyme family. Members of this family are involved in regulating intracellular concentrations of diacylglycerol and phosphatidic acid. Variation in this gene has been associated with bipolar disorder. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jul 2014]

DGKH Products (6)

mRNA Protein Name
NM_001204504.3 NP_001191433.1 diacylglycerol kinase eta isoform 1
NM_001204505.3 NP_001191434.1 diacylglycerol kinase eta isoform 3
NM_001204506.3 NP_001191435.1 diacylglycerol kinase eta isoform 4
NM_001297429.2 NP_001284358.1 diacylglycerol kinase eta isoform 5
NM_152910.6 NP_690874.2 diacylglycerol kinase eta isoform 1
NM_178009.5 NP_821077.1 diacylglycerol kinase eta isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP-dependent diacylglycerol kinase activity IDA
IDA: Inferred from direct assay
23949095 GOA
enables ATP-dependent diacylglycerol kinase activity IMP
IMP: Inferred from mutant phenotype
12810723 GOA
enables SAM domain binding IDA
IDA: Inferred from direct assay
12810723 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
12810723 GOA
enables kinase binding IPI
IPI: Inferred from physical interaction
12810723 GOA
Biological Process GO Annotation Evidence References Source
involved in phosphatidic acid metabolic process IDA
IDA: Inferred from direct assay
23949095 GOA
involved in phospholipase C/protein kinase C signal transduction IMP
IMP: Inferred from mutant phenotype
12810723 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12810723 GOA
located in endosome IDA
IDA: Inferred from direct assay
12810723 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
12810723 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DGKH Protein Structure

PH

PH: PH domain (67 - 157)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (176 - 226)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (248 - 299)

DAGK_cat

DAGK_cat: Diacylglycerol kinase catalytic domain (332 - 457)

DAGK_acc

DAGK_acc: Diacylglycerol kinase accessory domain (770 - 927)

SAM_2

SAM_2: SAM domain (Sterile alpha motif) (1151 - 1211)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1220 a.a.
Protein Preferred Names Protein Names

diacylglycerol kinase eta

  • DAG kinase eta

Related Diseases

Diseases Alias
Bipolar Disorder

  • Bipolar Depression

  • Manic Disorder

  • Depression, Bipolar

  • Bipolar Disorder Manic Phase

  • Depressive-Manic Psych.

  • Manic Bipolar Affective Disorder

  • Manic Bipolar I Disorder

  • Manic Depression

  • Manic Depressive Disorder

  • Mixed Bipolar Disorder

  • Bipolar Affective Disorder

  • Bipolar Affective Psychosis

  • Bipolar Spectrum Disorder

  • Manic Depressive Illness

  • Depression Bipolar

  • Bipolar Disorder, Mixed

  • Major Affective Disorder

  • Major Affective Disorder 1

  • Major Affective Disorder 2
Nephrolithiasis

  • Kidney Stones

  • Stone - Kidney/Ureter

  • Kidney Calculi
Attention Deficit-Hyperactivity Disorder

  • Attention Deficit Hyperactivity Disorder

  • ADHD

  • Attention Deficit Disorder

  • Attention Deficit-Hyperactivity Disorder, Susceptibility To

  • Attention Deficit Disorder With Hyperactivity

  • Hyperkinetic Disorder

  • Hyperactivity Of Childhood

  • Attention-Deficit/Hyperactivity Disorder

  • Add

  • Addh

  • Attention Deficit

  • Attention Deficit Disorder Of Childhood With Hyperactivity

  • Attention Deficit Disorder With Hyperactivity Syndrome

  • Hyperkinetic Syndrome

  • Attention-Deficit Hyperactivity Disorder

  • Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

  • Disturbance Of Activity And Attention

  • Disorder Of Activity And Attention

  • Adhd - [Attention Deficit Hyperactivity Disorder]

  • Hyperkinetic Disorders

  • Disorder Of Activity And Attention With Hyperkinesia

  • Attention Deficit Syndrome With Hyperactivity
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03720 DGKH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20713 Dgkh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27224 Dgkh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DGKH VGNC VGNC:61460
Canis familiaris DGKH VGNC VGNC:39920
Macaca mulatta DGKH VGNC VGNC:71786
Bos taurus DGKH VGNC VGNC:28029
Rattus norvegicus DGKH RGD RGD:1561955
Mus musculus DGKH MGD MGI:2444188
Others DGKH NCBI