Ikbkg - inhibitor of kappaB kinase gamma Gene

Also Known as NEMO; IKK[g]; 1110037D23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16151

Summary

Enables K63-linked polyubiquitin modification-dependent protein binding activity and identical protein binding activity. Involved in several processes, including anoikis; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; and positive regulation of macroautophagy. Acts upstream of or within B cell homeostasis and activation of NF-kappaB-inducing kinase activity. Located in cytoplasm. Is expressed in early conceptus; genitourinary system; and musculature. Used to study Bloch-Sulzberger syndrome and fatty liver disease. Human ortholog(s) of this gene implicated in Behcet's disease; Bloch-Sulzberger syndrome; immunodeficiency 33; and learning disability. Orthologous to human IKBKG (inhibitor of nuclear factor kappa B kinase regulatory subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]

Ikbkg Products (7)

mRNA Protein Name
NM_001136067.2 NP_001129539.1 NF-kappa-B essential modulator isoform 3
NM_001161421.1 NP_001154893.1 NF-kappa-B essential modulator isoform 4
NM_001161422.1 NP_001154894.1 NF-kappa-B essential modulator isoform 5
NM_001161423.1 NP_001154895.1 NF-kappa-B essential modulator isoform 1
NM_001161424.1 NP_001154896.1 NF-kappa-B essential modulator isoform 2
NM_010547.2 NP_034677.2 NF-kappa-B essential modulator isoform 1
NM_178590.4 NP_848705.1 NF-kappa-B essential modulator isoform 2
Protein Preferred Names Protein Names

NF-kappa-B essential modulator

  • I-kappa-B kinase subunit gamma

  • IKK-gamma

  • IKKAP1

  • IKKG

  • NF-kappa-B essential modifier

  • ikB kinase subunit gamma

  • ikB kinase-associated protein 1

  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

  • inhibitor of nuclear factor kap

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06664 IKBKG Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ikbkg NCBI NCBI:8517