Inpp5b - inositol polyphosphate-5-phosphatase B Gene

Also Known as 5PTase; INPP5P

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16330

Summary

This gene encodes a member of the inositol polyphosphate-5-phosphatase (INPP5) family. This protein hydrolyzes the 5' phosphate from phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol-1,4,5-trisphosphate, which results in changes to multiple signaling pathways. This protein may be involved in protein trafficking and secretion. Homozygous knockout mice exhibit impaired spermatogenesis and male sterility. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Inpp5b Products (1)

mRNA Protein Name
NM_008385.4 NP_032411.3 type II inositol 1,4,5-trisphosphate 5-phosphatase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables inositol-1,4,5-trisphosphate 5-phosphatase activity IDA
IDA: Inferred from direct assay
9525932 MGI
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IDA
IDA: Inferred from direct assay
9525932 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within flagellated sperm motility IMP
IMP: Inferred from mutant phenotype
11784089 MGI
acts upstream of or within in utero embryonic development IGI
IGI: Inferred from genetic interaction
20195868 MGI
involved in phosphatidylinositol dephosphorylation IDA
IDA: Inferred from direct assay
9525932 MGI
acts upstream of or within regulation of protein processing IMP
IMP: Inferred from mutant phenotype
11784089 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
11784089 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
9525932 MGI
located in membrane IDA
IDA: Inferred from direct assay
9525932 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

type II inositol 1,4,5-trisphosphate 5-phosphatase

  • inositol polyphosphate-5-phosphatase, 75 kDa

  • phosphoinositide 5-phosphatase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120354 YU142670 Inhibitor 99.50% Unkown
HY-RS06828 INPP5B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Inpp5b NCBI NCBI:3633