Inpp5b - inositol polyphosphate-5-phosphatase B Gene

Mus musculus

Also known as 5PTase; INPP5P

Gene ID: 16330 | Gene type: protein coding

About Inpp5b

Summary

This gene encodes a member of the inositol polyphosphate-5-phosphatase (INPP5) family. This protein hydrolyzes the 5' phosphate from phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol-1,4,5-trisphosphate, which results in changes to multiple signaling pathways. This protein may be involved in protein trafficking and secretion. Homozygous knockout mice exhibit impaired spermatogenesis and male sterility. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Inpp5b Products(1)

mRNA	Protein	Name
NM_008385.4	NP_032411.3	type II inositol 1,4,5-trisphosphate 5-phosphatase precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables inositol-1,4,5-trisphosphate 5-phosphatase activity	IDA IDA: Inferred from direct assay	9525932	MGI
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IDA IDA: Inferred from direct assay	9525932	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within flagellated sperm motility	IMP IMP: Inferred from mutant phenotype	11784089	MGI
acts upstream of or within in utero embryonic development	IGI IGI: Inferred from genetic interaction	20195868	MGI
involved in phosphatidylinositol dephosphorylation	IDA IDA: Inferred from direct assay	9525932	MGI
acts upstream of or within regulation of protein processing	IMP IMP: Inferred from mutant phenotype	11784089	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	11784089	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	9525932	MGI
located in membrane	IDA IDA: Inferred from direct assay	9525932	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

type II inositol 1,4,5-trisphosphate 5-phosphatase

inositol polyphosphate-5-phosphatase, 75 kDa

phosphoinositide 5-phosphatase

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120354	YU142670	Inhibitor	99.50%	Unkown
HY-RS06828	INPP5B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Inpp5b	NCBI	NCBI:3633

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