DENND1B - DENN domain containing 1B Gene

Homo sapiens

Also known as FAM31B; C1ORF18; C1orf218

Gene ID: 163486 | Gene type: protein coding

About DENND1B

Cytogenetic location: 1q31.3 Genomic coordinates (GRCh38): 1:197,504,748-197,782,150 (from NCBI)

This gene has 11 transcripts (splice variants), 226 orthologues and 2 paralogues. Ubiquitous expression in colon (RPKM 1.5), thyroid (RPKM 1.4) and 25 other tissues.

Summary

Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]

DENND1B Products(4)

mRNA	Protein	Name
NM_001195215.2	NP_001182144.1	DENN domain-containing protein 1B isoform 3
NM_001195216.2	NP_001182145.1	DENN domain-containing protein 1B isoform 4
NM_001300858.2	NP_001287787.1	DENN domain-containing protein 1B isoform 5
NM_144977.5	NP_659414.2	DENN domain-containing protein 1B isoform 2

DENND1B Protein Structure

uDENN

DENN

dDENN

0
100
200
300
400
426 a.a.

Protein Preferred Names

Protein Names

DENN domain-containing protein 1B

DENN/MADD domain containing 1B

Related Diseases

Diseases

Alias

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Childhood-Onset Asthma

Childhood Asthma

Asthma Childhood

Primary Biliary Cholangitis

Primary Biliary Cirrhosis	Biliary Liver Cirrhosis
Chronic Nonsuppurative Destructive Cholangitis	Familial Primary Biliary Cirrhosis
Pbc	Hanot Syndrome
Cholestatic Cirrhosis	Biliary Cirrhosis Primary
Liver Cirrhosis, Biliary	Hanot'S Cirrhosis
Biliary Cirrhosis	Pericholangiolic Biliary Cirrhosis
Tannhauser-Magendantz Syndrome	Hanot-Rossle Syndrome
Hypertrophic Cirrhosis	Todd Cirrhosis
Hanot Cirrhosis	Charcot Cirrhosis
Mahon-Tannhauser Syndrome	Toxic Cirrhosis
Hypertrophic Biliary Cirrhosis	Monolobular Cirrhosis
Unilobar Cirrhosis	Xanthomatous Biliary Cirrhosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03686	DENND1B Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DENND1B	VGNC	VGNC:106709
Macaca mulatta	DENND1B	VGNC	VGNC:99884
Rattus norvegicus	DENND1B	RGD	RGD:1308441
Mus musculus	DENND1B	MGD	MGI:2447812
Canis familiaris	DENND1B	VGNC	VGNC:53340
Felis catus	DENND1B	VGNC	VGNC:107866

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