2. Gene
  3. Irx2 - Iroquois homeobox 2 Gene

Irx2 - Iroquois homeobox 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 16372 | Gene type: protein coding

About Irx2

Summary

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within proximal/distal pattern formation involved in metanephric nephron development and specification of loop of Henle identity. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; autopod; central nervous system; genitourinary system; and respiratory system. Orthologous to human IRX2 (iroquois homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Irx2 Products(1)

mRNA Protein Name
NM_010574.4 NP_034704.1 iroquois-class homeodomain protein IRX-2
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in metanephros development IEP
IEP: Inferred from expression pattern
17875669 MGI
involved in proximal/distal pattern formation involved in metanephric nephron development IEP
IEP: Inferred from expression pattern
17875669 MGI
involved in specification of loop of Henle identity IEP
IEP: Inferred from expression pattern
17875669 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

iroquois-class homeodomain protein IRX-2

Iroquois related homeobox 2

homeodomain protein IRXA2

iroquois homeobox protein 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06921 IRX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Irx2 NCBI NCBI:153572