Eif6 - eukaryotic translation initiation factor 6 Gene

Mus musculus

Also known as CAB; eIF-6; p27BBP; Itgb4bp; imc-415; p27(BBP); 1110004P11

Gene ID: 16418 | Gene type: protein coding

About Eif6

Summary

The protein encoded by this gene is a eukaryotic translation initiation factor that regulates both ribosome biogenesis and translation, which are rate-limiting factors for cell growth. The encoded protein binds 60S ribosomes and prevents their association with 40S ribosomes. This gene may play a role in oncogenesis as well. [provided by RefSeq, Aug 2015]

Eif6 Products(1)

mRNA	Protein	Name
NM_010579.2	NP_034709.1	eukaryotic translation initiation factor 6

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of translation	IMP IMP: Inferred from mutant phenotype	26383020	MGI
involved in regulation of fatty acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	26383020	MGI
involved in regulation of glycolytic process	IMP IMP: Inferred from mutant phenotype	26383020	MGI
involved in regulation of megakaryocyte differentiation	IMP IMP: Inferred from mutant phenotype	26391622	MGI
involved in regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	26391622	MGI
involved in response to insulin	IMP IMP: Inferred from mutant phenotype	26383020	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in intermediate filament	IDA IDA: Inferred from direct assay	9374518	MGI
located in lamin filament	IDA IDA: Inferred from direct assay	9374518	MGI
is active in synapse	EXP EXP: Inferred from Experiment	25211037	MGI
is active in synapse	IDA IDA: Inferred from direct assay	25211037	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 6

B4 integrin interactor

integrin beta 4 binding protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04289	EIF6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Eif6	NCBI	NCBI:3692

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