Eif6 - eukaryotic translation initiation factor 6 Gene

Also Known as CAB; eIF-6; p27BBP; Itgb4bp; imc-415; p27(BBP); 1110004P11

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16418

Summary

The protein encoded by this gene is a eukaryotic translation initiation factor that regulates both ribosome biogenesis and translation, which are rate-limiting factors for cell growth. The encoded protein binds 60S ribosomes and prevents their association with 40S ribosomes. This gene may play a role in oncogenesis as well. [provided by RefSeq, Aug 2015]

Eif6 Products (1)

mRNA Protein Name
NM_010579.2 NP_034709.1 eukaryotic translation initiation factor 6

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in positive regulation of translation IMP
IMP: Inferred from mutant phenotype
26383020 MGI
involved in regulation of fatty acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
26383020 MGI
involved in regulation of glycolytic process IMP
IMP: Inferred from mutant phenotype
26383020 MGI
involved in regulation of megakaryocyte differentiation IMP
IMP: Inferred from mutant phenotype
26391622 MGI
involved in regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
26391622 MGI
involved in response to insulin IMP
IMP: Inferred from mutant phenotype
26383020 MGI
Cellular Component GO Annotation Evidence References Source
located in intermediate filament IDA
IDA: Inferred from direct assay
9374518 MGI
located in lamin filament IDA
IDA: Inferred from direct assay
9374518 MGI
is active in synapse EXP
EXP: Inferred from Experiment
25211037 MGI
is active in synapse IDA
IDA: Inferred from direct assay
25211037 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 6

  • B4 integrin interactor

  • integrin beta 4 binding protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04289 EIF6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eif6 NCBI NCBI:3692