Itpr1 - inositol 1,4,5-trisphosphate receptor 1 Gene

Mus musculus

Also known as opt; Ip3r; P400; Pcp1; wblo; IP3R1; Pcp-1; D6Pas2; IP3R 1; InsP3R; Itpr-1; Gm10429; insP3R1

Gene ID: 16438 | Gene type: protein coding

About Itpr1

Summary

Enables inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels; phosphatidylinositol binding activity; and protein domain specific binding activity. Involved in several processes, including epithelial fluid transport; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and release of sequestered calcium ion into cytosol. Acts upstream of or within several processes, including calcium ion transport; endoplasmic reticulum calcium ion homeostasis; and voluntary musculoskeletal movement. Located in endoplasmic reticulum; nucleus; and postsynaptic density. Part of Calcineurin complex. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including brain; brown fat; genitourinary system; heart; and hemolymphoid system. Human ortholog(s) of this gene implicated in Gillespie syndrome; spinocerebellar ataxia type 15; and spinocerebellar ataxia type 29. Orthologous to human ITPR1 (inositol 1,4,5-trisphosphate receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]

Itpr1 Products(1)

mRNA	Protein	Name
NM_010585.5	NP_034715.3	inositol 1,4,5-trisphosphate receptor type 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables inositol 1,4,5 trisphosphate binding	IDA IDA: Inferred from direct assay	2554142	MGI
enables inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels	EXP EXP: Inferred from Experiment	11117745	MGI
enables inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels	IDA IDA: Inferred from direct assay	11117745	MGI
enables inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels	IMP IMP: Inferred from mutant phenotype	11117745	MGI
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	IDA IDA: Inferred from direct assay	2554142	MGI
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	IGI IGI: Inferred from genetic interaction	10570150	MGI
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	IMP IMP: Inferred from mutant phenotype	35568199	MGI
enables intracellularly gated calcium channel activity	IDA IDA: Inferred from direct assay	20813840	MGI
enables phosphatidylinositol binding	IDA IDA: Inferred from direct assay	8663526	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10051594	MGI
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	32675284	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	28416699	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within calcium ion transport	IDA IDA: Inferred from direct assay	16014380	MGI
involved in cell morphogenesis	IMP IMP: Inferred from mutant phenotype	32675284	MGI
acts upstream of or within endoplasmic reticulum calcium ion homeostasis	IGI IGI: Inferred from genetic interaction	15613488	MGI
involved in epithelial fluid transport	IDA IDA: Inferred from direct assay	23542070	MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	19752026	MGI
involved in ion channel modulating, G protein-coupled receptor signaling pathway	IGI IGI: Inferred from genetic interaction	10570150	MGI
involved in ion channel modulating, G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	31664108	MGI
involved in ligand-gated ion channel signaling pathway	IGI IGI: Inferred from genetic interaction	10570150	MGI
involved in ligand-gated ion channel signaling pathway	IMP IMP: Inferred from mutant phenotype	26075576	MGI
involved in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	IGI IGI: Inferred from genetic interaction	10570150	MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	26075576	MGI
involved in positive regulation of insulin secretion	IGI IGI: Inferred from genetic interaction	10570150	MGI
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	26075576	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	17590087	MGI
involved in protein homotetramerization	IDA IDA: Inferred from direct assay	35568199	MGI
involved in regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	38099643	MGI
involved in release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	19752026	MGI
involved in response to hypoxia	IDA IDA: Inferred from direct assay	19120137	MGI
involved in single fertilization	IDA IDA: Inferred from direct assay	38099643	MGI
acts upstream of or within voluntary musculoskeletal movement	IMP IMP: Inferred from mutant phenotype	17590087	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	EXP EXP: Inferred from Experiment	11117745	MGI
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	11117745	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	11117745	MGI
part of calcineurin complex	IDA IDA: Inferred from direct assay	12617961	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	9858485	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	24374158	MGI
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	15613488	MGI
located in nuclear envelope	IDA IDA: Inferred from direct assay	16014380	MGI
located in nuclear inner membrane	IDA IDA: Inferred from direct assay	16014380	MGI
located in nucleolus	IDA IDA: Inferred from direct assay	16014380	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	15579147	MGI
part of protein-containing complex	IPI IPI: Inferred from physical interaction	17416589	MGI
located in sarcoplasmic reticulum	IDA IDA: Inferred from direct assay	16014380	MGI
is active in synapse	IPI IPI: Inferred from physical interaction	32675284	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

inositol 1,4,5-trisphosphate receptor type 1

IP3 receptor	InsP>3
Purkinje cell protein 1	inositol 1,4,5-trisphosphate-binding protein P400
opisthotonus	protein PCD-6
type 1 InsP3 receptor	type 1 inositol 1,4,5-trisphosphate receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163171	ARN11391		99.40%	Unkown
HY-RS29492	Itpr1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06991	ITPR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Itpr1	NCBI	NCBI:3708

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