Itpr1 - inositol 1,4,5-trisphosphate receptor 1 Gene

Also Known as opt; Ip3r; P400; Pcp1; wblo; IP3R1; Pcp-1; D6Pas2; IP3R 1; InsP3R; Itpr-1; Gm10429; insP3R1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16438

Summary

Enables inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels; phosphatidylinositol binding activity; and protein domain specific binding activity. Involved in several processes, including epithelial fluid transport; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and release of sequestered calcium ion into cytosol. Acts upstream of or within several processes, including calcium ion transport; endoplasmic reticulum calcium ion homeostasis; and voluntary musculoskeletal movement. Located in endoplasmic reticulum; nucleus; and postsynaptic density. Part of Calcineurin complex. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including brain; brown fat; genitourinary system; heart; and hemolymphoid system. Human ortholog(s) of this gene implicated in Gillespie syndrome; spinocerebellar ataxia type 15; and spinocerebellar ataxia type 29. Orthologous to human ITPR1 (inositol 1,4,5-trisphosphate receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]

Itpr1 Products (1)

mRNA Protein Name
NM_010585.5 NP_034715.3 inositol 1,4,5-trisphosphate receptor type 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables inositol 1,4,5 trisphosphate binding IDA
IDA: Inferred from direct assay
2554142 MGI
enables inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels EXP
EXP: Inferred from Experiment
11117745 MGI
enables inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels IDA
IDA: Inferred from direct assay
11117745 MGI
enables inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels IMP
IMP: Inferred from mutant phenotype
11117745 MGI
enables inositol 1,4,5-trisphosphate-gated calcium channel activity IDA
IDA: Inferred from direct assay
2554142 MGI
enables inositol 1,4,5-trisphosphate-gated calcium channel activity IGI
IGI: Inferred from genetic interaction
10570150 MGI
enables inositol 1,4,5-trisphosphate-gated calcium channel activity IMP
IMP: Inferred from mutant phenotype
35568199 MGI
enables intracellularly gated calcium channel activity IDA
IDA: Inferred from direct assay
20813840 MGI
enables phosphatidylinositol binding IDA
IDA: Inferred from direct assay
8663526 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10051594 MGI
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
32675284 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
28416699 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within calcium ion transport IDA
IDA: Inferred from direct assay
16014380 MGI
involved in cell morphogenesis IMP
IMP: Inferred from mutant phenotype
32675284 MGI
acts upstream of or within endoplasmic reticulum calcium ion homeostasis IGI
IGI: Inferred from genetic interaction
15613488 MGI
involved in epithelial fluid transport IDA
IDA: Inferred from direct assay
23542070 MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
19752026 MGI
involved in ion channel modulating, G protein-coupled receptor signaling pathway IGI
IGI: Inferred from genetic interaction
10570150 MGI
involved in ion channel modulating, G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
31664108 MGI
involved in ligand-gated ion channel signaling pathway IGI
IGI: Inferred from genetic interaction
10570150 MGI
involved in ligand-gated ion channel signaling pathway IMP
IMP: Inferred from mutant phenotype
26075576 MGI
involved in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway IGI
IGI: Inferred from genetic interaction
10570150 MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
26075576 MGI
involved in positive regulation of insulin secretion IGI
IGI: Inferred from genetic interaction
10570150 MGI
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
26075576 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
17590087 MGI
involved in protein homotetramerization IDA
IDA: Inferred from direct assay
35568199 MGI
involved in regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
38099643 MGI
involved in release of sequestered calcium ion into cytosol IMP
IMP: Inferred from mutant phenotype
19752026 MGI
involved in response to hypoxia IDA
IDA: Inferred from direct assay
19120137 MGI
involved in single fertilization IDA
IDA: Inferred from direct assay
38099643 MGI
acts upstream of or within voluntary musculoskeletal movement IMP
IMP: Inferred from mutant phenotype
17590087 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse EXP
EXP: Inferred from Experiment
11117745 MGI
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
11117745 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
11117745 MGI
part of calcineurin complex IDA
IDA: Inferred from direct assay
12617961 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
9858485 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
24374158 MGI
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
15613488 MGI
located in nuclear envelope IDA
IDA: Inferred from direct assay
16014380 MGI
located in nuclear inner membrane IDA
IDA: Inferred from direct assay
16014380 MGI
located in nucleolus IDA
IDA: Inferred from direct assay
16014380 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
15579147 MGI
part of protein-containing complex IPI
IPI: Inferred from physical interaction
17416589 MGI
located in sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
16014380 MGI
is active in synapse IPI
IPI: Inferred from physical interaction
32675284 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inositol 1,4,5-trisphosphate receptor type 1

  • IP3 receptor

  • InsP>3

  • Purkinje cell protein 1

  • inositol 1,4,5-trisphosphate-binding protein P400

  • opisthotonus

  • protein PCD-6

  • type 1 InsP3 receptor

  • type 1 inositol 1,4,5-trisphosphate receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-163171 ARN11391 99.40% Unkown
HY-RS29492 Itpr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06991 ITPR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itpr1 NCBI NCBI:3708