Jag2 - jagged 2 Gene

Also Known as sm; Serh; D12Ggc2e; mJagged2-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16450

Summary

Enables Notch binding activity. Involved in auditory receptor cell fate commitment; gamma-delta T cell differentiation; and positive regulation of Notch signaling pathway. Acts upstream of or within several processes, including epithelial cell apoptotic process involved in palatal shelf morphogenesis; odontogenesis of dentin-containing tooth; and respiratory system process. Located in membrane. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; sensory organ; and surface ectoderm. Orthologous to human JAG2 (jagged canonical Notch ligand 2). [provided by Alliance of Genome Resources, Apr 2022]

Jag2 Products (2)

mRNA	Protein	Name
NM_001409685.1	NP_001396614.1	protein jagged-2 isoform 2 precursor
NM_010588.3	NP_034718.2	protein jagged-2 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Notch binding	IPI IPI: Inferred from physical interaction	10958687	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12496659	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in auditory receptor cell fate commitment	IMP IMP: Inferred from mutant phenotype	10080181	MGI
acts upstream of or within epithelial cell apoptotic process involved in palatal shelf morphogenesis	IMP IMP: Inferred from mutant phenotype	16607638	MGI
involved in gamma-delta T cell differentiation	IMP IMP: Inferred from mutant phenotype	10383933	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	9531541	MGI
acts upstream of or within morphogenesis of embryonic epithelium	IMP IMP: Inferred from mutant phenotype	16607638	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IMP IMP: Inferred from mutant phenotype	15721140	MGI
involved in positive regulation of Notch signaling pathway	IDA IDA: Inferred from direct assay	10958687	MGI
acts upstream of or within regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	16607638	MGI
acts upstream of or within respiratory system process	IMP IMP: Inferred from mutant phenotype	9531541	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	15721140	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in membrane	IDA IDA: Inferred from direct assay	15886206	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	10910909	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein jagged-2	syndactylism

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07013	JAG2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19343	Jag2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25834	Jag2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Jag2	NCBI	NCBI:3714