Kcna1 - potassium voltage-gated channel, shaker-related subfamily, member 1 Gene

Also Known as MBK1; Mk-1; Shak; Kv1.1; mceph; Kca1-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16485

Summary

Enables delayed rectifier Potassium Channel activity. Involved in several processes, including cellular response to magnesium ion; detection of mechanical stimulus involved in sensory perception; and nervous system development. Located in several cellular components, including axon; dendrite; and neuronal cell body. Is integral component of plasma membrane. Part of voltage-gated Potassium Channel complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; immune system; and nervous system. Used to study epilepsy; episodic ataxia type 1; and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in episodic ataxia type 1. Orthologous to human KCNA1 (potassium voltage-gated channel subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Kcna1 Products (1)

mRNA	Protein	Name
NM_010595.3	NP_034725.3	potassium voltage-gated channel subfamily A member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables delayed rectifier potassium channel activity	IDA IDA: Inferred from direct assay	15361858	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	25707359	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in brain development	IMP IMP: Inferred from mutant phenotype	21966978	MGI
involved in cellular response to magnesium ion	IMP IMP: Inferred from mutant phenotype	23903368	MGI
involved in detection of mechanical stimulus involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	23473320	MGI
involved in detection of mechanical stimulus involved in sensory perception of touch	IMP IMP: Inferred from mutant phenotype	23473320	MGI
involved in hippocampus development	IMP IMP: Inferred from mutant phenotype	17315199	MGI
involved in membrane repolarization during action potential	IDA IDA: Inferred from direct assay	15361858	MGI
involved in neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	17315199	MGI
involved in neuromuscular process	IMP IMP: Inferred from mutant phenotype	9736643	MGI
involved in neuronal action potential	IMP IMP: Inferred from mutant phenotype	9736643	MGI
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	15361858	MGI
involved in startle response	IMP IMP: Inferred from mutant phenotype	21966978	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	8046438	MGI
is active in axon initial segment	IDA IDA: Inferred from direct assay	18509034	MGI
located in axon terminus	IDA IDA: Inferred from direct assay	21233214	MGI
located in cell junction	IDA IDA: Inferred from direct assay	8046438	MGI
located in cell surface	IDA IDA: Inferred from direct assay	23836929	MGI
located in dendrite	IDA IDA: Inferred from direct assay	8046438	MGI
located in juxtaparanode region of axon	IDA IDA: Inferred from direct assay	8361541	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	8046438	MGI
located in paranode region of axon	IDA IDA: Inferred from direct assay	8046438	MGI
located in perikaryon	IDA IDA: Inferred from direct assay	26269648	MGI
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	15361858	MGI
located in synapse	IDA IDA: Inferred from direct assay	8046438	MGI
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	8361541	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
potassium voltage-gated channel subfamily A member 1	MKI brain potassium channel protein-1 megencephaly voltage-gated potassium channel subunit Kv1.1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07097	KCNA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcna1	NCBI	NCBI:3736