Kcna2 - potassium voltage-gated channel, shaker-related subfamily, member 2 Gene

Mus musculus

Also known as Mk-2; Kv1.2; Akr6a4; Kca1-2; Gm10672

Gene ID: 16490 | Gene type: protein coding

About Kcna2

Summary

Enables voltage-gated Potassium Channel activity. Involved in potassium ion transmembrane transport; regulation of circadian sleep/wake cycle, non-REM sleep; and regulation of dopamine secretion. Acts upstream of or within optic nerve structural organization. Located in several cellular components, including axon; neuronal cell body membrane; and perikaryon. Is integral component of plasma membrane. Part of voltage-gated Potassium Channel complex. Is expressed in brain; heart ventricle; hindlimb muscle; and thalamus mantle layer. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 32. Orthologous to human KCNA2 (potassium voltage-gated channel subfamily A member 2). [provided by Alliance of Genome Resources, Apr 2022]

Kcna2 Products(1)

mRNA	Protein	Name
NM_008417.5	NP_032443.3	potassium voltage-gated channel subfamily A member 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17959782	MGI
enables voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	9635436	MGI
enables voltage-gated potassium channel activity	IMP IMP: Inferred from mutant phenotype	20696761	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within optic nerve structural organization	IMP IMP: Inferred from mutant phenotype	15102918	MGI
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	21233214	MGI
involved in regulation of circadian sleep/wake cycle, non-REM sleep	IMP IMP: Inferred from mutant phenotype	17925011	MGI
involved in regulation of dopamine secretion	IMP IMP: Inferred from mutant phenotype	21233214	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	21233214	MGI
is active in axon initial segment	IDA IDA: Inferred from direct assay	18509034	MGI
located in axon terminus	IDA IDA: Inferred from direct assay	21233214	MGI
located in dendrite	IDA IDA: Inferred from direct assay	8046438	MGI
located in juxtaparanode region of axon	IDA IDA: Inferred from direct assay	12963709	MGI
located in neuronal cell body membrane	IDA IDA: Inferred from direct assay	8046438	MGI
located in perikaryon	IDA IDA: Inferred from direct assay	8046438	MGI
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	21233214	MGI
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	12975355	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

potassium voltage-gated channel subfamily A member 2

MK2	voltage-gated potassium channel subunit Kv1.2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07098	KCNA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcna2	NCBI	NCBI:3737

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