Kcna2 - potassium voltage-gated channel, shaker-related subfamily, member 2 Gene

Also Known as Mk-2; Kv1.2; Akr6a4; Kca1-2; Gm10672

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16490

Summary

Enables voltage-gated Potassium Channel activity. Involved in potassium ion transmembrane transport; regulation of circadian sleep/wake cycle, non-REM sleep; and regulation of dopamine secretion. Acts upstream of or within optic nerve structural organization. Located in several cellular components, including axon; neuronal cell body membrane; and perikaryon. Is integral component of plasma membrane. Part of voltage-gated Potassium Channel complex. Is expressed in brain; heart ventricle; hindlimb muscle; and thalamus mantle layer. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 32. Orthologous to human KCNA2 (potassium voltage-gated channel subfamily A member 2). [provided by Alliance of Genome Resources, Apr 2022]

Kcna2 Products (1)

mRNA Protein Name
NM_008417.5 NP_032443.3 potassium voltage-gated channel subfamily A member 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17959782 MGI
enables voltage-gated potassium channel activity IDA
IDA: Inferred from direct assay
9635436 MGI
enables voltage-gated potassium channel activity IMP
IMP: Inferred from mutant phenotype
20696761 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within optic nerve structural organization IMP
IMP: Inferred from mutant phenotype
15102918 MGI
involved in potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
21233214 MGI
involved in regulation of circadian sleep/wake cycle, non-REM sleep IMP
IMP: Inferred from mutant phenotype
17925011 MGI
involved in regulation of dopamine secretion IMP
IMP: Inferred from mutant phenotype
21233214 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
21233214 MGI
is active in axon initial segment IDA
IDA: Inferred from direct assay
18509034 MGI
located in axon terminus IDA
IDA: Inferred from direct assay
21233214 MGI
located in dendrite IDA
IDA: Inferred from direct assay
8046438 MGI
located in juxtaparanode region of axon IDA
IDA: Inferred from direct assay
12963709 MGI
located in neuronal cell body membrane IDA
IDA: Inferred from direct assay
8046438 MGI
located in perikaryon IDA
IDA: Inferred from direct assay
8046438 MGI
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
21233214 MGI
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
12975355 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily A member 2

  • MK2

  • voltage-gated potassium channel subunit Kv1.2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07098 KCNA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcna2 NCBI NCBI:3737