Kcnb1 - potassium voltage gated channel, Shab-related subfamily, member 1 Gene

Also Known as Shab; Kv2.1; Kcr1-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16500

Summary

Enables delayed rectifier Potassium Channel activity. Involved in several processes, including cellular response to glucose stimulus; negative regulation of Insulin secretion; and positive regulation of long-term synaptic depression. Located in dendrite and neuronal cell body membrane. Part of voltage-gated Potassium Channel complex. Is expressed in several structures, including adipose tissue; brain; cardiovascular system; genitourinary system; and gut. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 26 and epilepsy. Orthologous to human KCNB1 (potassium voltage-gated channel subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]

Kcnb1 Products (1)

mRNA Protein Name
NM_008420.4 NP_032446.2 potassium voltage-gated channel subfamily B member 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables delayed rectifier potassium channel activity IDA
IDA: Inferred from direct assay
2002364 MGI
enables delayed rectifier potassium channel activity IMP
IMP: Inferred from mutant phenotype
17767909 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8576199 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to glucose stimulus IDA
IDA: Inferred from direct assay
17767909 MGI
involved in glucose homeostasis IMP
IMP: Inferred from mutant phenotype
17767909 MGI
involved in negative regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
17767909 MGI
involved in positive regulation of long-term synaptic depression IMP
IMP: Inferred from mutant phenotype
24494598 MGI
involved in potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
22056818 MGI
involved in potassium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
17767909 MGI
involved in regulation of action potential IMP
IMP: Inferred from mutant phenotype
17767909 MGI
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
22056818 MGI
located in neuronal cell body membrane IDA
IDA: Inferred from direct assay
22056818 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
17767909 MGI
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
22056818 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily B member 1

  • voltage-gated potassium channel subunit Kv2.1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07106 KCNB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnb1 NCBI NCBI:3745