Kcnb1 - potassium voltage gated channel, Shab-related subfamily, member 1 Gene

Mus musculus

Also known as Shab; Kv2.1; Kcr1-1

Gene ID: 16500 | Gene type: protein coding

About Kcnb1

Summary

Enables delayed rectifier Potassium Channel activity. Involved in several processes, including cellular response to glucose stimulus; negative regulation of Insulin secretion; and positive regulation of long-term synaptic depression. Located in dendrite and neuronal cell body membrane. Part of voltage-gated Potassium Channel complex. Is expressed in several structures, including adipose tissue; brain; cardiovascular system; genitourinary system; and gut. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 26 and epilepsy. Orthologous to human KCNB1 (potassium voltage-gated channel subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]

Kcnb1 Products(1)

mRNA	Protein	Name
NM_008420.4	NP_032446.2	potassium voltage-gated channel subfamily B member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables delayed rectifier potassium channel activity	IDA IDA: Inferred from direct assay	2002364	MGI
enables delayed rectifier potassium channel activity	IMP IMP: Inferred from mutant phenotype	17767909	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8576199	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to glucose stimulus	IDA IDA: Inferred from direct assay	17767909	MGI
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	17767909	MGI
involved in negative regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	17767909	MGI
involved in positive regulation of long-term synaptic depression	IMP IMP: Inferred from mutant phenotype	24494598	MGI
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	22056818	MGI
involved in potassium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	17767909	MGI
involved in regulation of action potential	IMP IMP: Inferred from mutant phenotype	17767909	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendrite	IDA IDA: Inferred from direct assay	22056818	MGI
located in neuronal cell body membrane	IDA IDA: Inferred from direct assay	22056818	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	17767909	MGI
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	22056818	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

potassium voltage-gated channel subfamily B member 1

voltage-gated potassium channel subunit Kv2.1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07106	KCNB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcnb1	NCBI	NCBI:3745

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