Kcnc3 - potassium voltage gated channel, Shaw-related subfamily, member 3 Gene

Also Known as Kv3.3; Kcr2-3; KShIIID

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16504

Summary

Predicted to enable delayed rectifier Potassium Channel activity. Acts upstream of or within regulation of neurotransmitter secretion. Located in several cellular components, including neuromuscular junction; neuron projection membrane; and neuronal cell body membrane. Is expressed in aortic valve; arch of aorta; brain; descending thoracic aorta; and thoracic aorta. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 13. Orthologous to human KCNC3 (potassium voltage-gated channel subfamily C member 3). [provided by Alliance of Genome Resources, Apr 2022]

Kcnc3 Products (15)

mRNA Protein Name
NM_001290682.2 NP_001277611.1 potassium voltage-gated channel subfamily C member 3 isoform 2
NM_001385625.1 NP_001372554.1 potassium voltage-gated channel subfamily C member 3 isoform 3
NM_001385626.1 NP_001372555.1 potassium voltage-gated channel subfamily C member 3 isoform 4
NM_001385627.1 NP_001372556.1 potassium voltage-gated channel subfamily C member 3 isoform 5
NM_001385628.1 NP_001372557.1 potassium voltage-gated channel subfamily C member 3 isoform 6
NM_001385629.1 NP_001372558.1 potassium voltage-gated channel subfamily C member 3 isoform 7
NM_001385630.1 NP_001372559.1 potassium voltage-gated channel subfamily C member 3 isoform 7
NM_001385631.1 NP_001372560.1 potassium voltage-gated channel subfamily C member 3 isoform 2
NM_001385632.1 NP_001372561.1 potassium voltage-gated channel subfamily C member 3 isoform 8
NM_001385633.1 NP_001372562.1 potassium voltage-gated channel subfamily C member 3 isoform 8
NM_001385634.1 NP_001372563.1 potassium voltage-gated channel subfamily C member 3 isoform 9
NM_001385635.1 NP_001372564.1 potassium voltage-gated channel subfamily C member 3 isoform 10
NM_001385636.1 NP_001372565.1 potassium voltage-gated channel subfamily C member 3 isoform 11
NM_001385637.1 NP_001372566.1 potassium voltage-gated channel subfamily C member 3 isoform 12
NM_008422.3 NP_032448.2 potassium voltage-gated channel subfamily C member 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables voltage-gated potassium channel activity IDA
IDA: Inferred from direct assay
15217387 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within regulation of neurotransmitter secretion IMP
IMP: Inferred from mutant phenotype
15610163 MGI
involved in regulation of synaptic vesicle endocytosis IDA
IDA: Inferred from direct assay
33508244 MGI
involved in regulation of synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
33508244 MGI
Cellular Component GO Annotation Evidence References Source
located in axolemma IDA
IDA: Inferred from direct assay
18682278 MGI
located in axon terminus IDA
IDA: Inferred from direct assay
15610163 MGI
is active in calyx of Held IDA
IDA: Inferred from direct assay
33508244 MGI
is active in calyx of Held IMP
IMP: Inferred from mutant phenotype
33508244 MGI
located in dendrite IDA
IDA: Inferred from direct assay
15217387 MGI
located in dendrite membrane IDA
IDA: Inferred from direct assay
18682278 MGI
located in neuromuscular junction IDA
IDA: Inferred from direct assay
15610163 MGI
located in neuronal cell body membrane IDA
IDA: Inferred from direct assay
18682278 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily C member 3

  • voltage-gated potassium channel subunit Kv3.3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07110 KCNC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22585 Kcnc3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnc3 NCBI NCBI:3748