2. Gene
  3. Kcnh1 - potassium voltage-gated channel, subfamily H (eag-related), member 1 Gene

Kcnh1 - potassium voltage-gated channel, subfamily H (eag-related), member 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as EAG1; M-eag; Kv10.1

Gene ID: 16510 | Gene type: protein coding

About Kcnh1

Summary

Enables delayed rectifier Potassium Channel activity and voltage-gated ion channel activity involved in regulation of presynaptic membrane potential. Involved in potassium ion transmembrane transport; regulation of presynaptic cytosolic calcium ion concentration; and regulation of synaptic vesicle exocytosis. Is integral component of plasma membrane. Is active in parallel fiber to Purkinje cell synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human KCNH1 (potassium voltage-gated channel subfamily H member 1). [provided by Alliance of Genome Resources, Apr 2022]

Kcnh1 Products(2)

mRNA Protein Name
NM_001038607.2 NP_001033696.1 potassium voltage-gated channel subfamily H member 1 isoform 2
NM_010600.3 NP_034730.1 potassium voltage-gated channel subfamily H member 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
NOT enables cyclic nucleotide binding IDA
IDA: Inferred from direct assay
19671703 MGI
enables delayed rectifier potassium channel activity IDA
IDA: Inferred from direct assay
19671703 MGI
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
IDA: Inferred from direct assay
25556795 MGI
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
25556795 MGI
Biological Process GO Annotation Evidence Reference Source
involved in potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
19671703 MGI
involved in regulation of presynaptic cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
25556795 MGI
involved in regulation of presynaptic cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
25556795 MGI
involved in regulation of synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
25556795 MGI
involved in regulation of synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
25556795 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in parallel fiber to Purkinje cell synapse IDA
IDA: Inferred from direct assay
25556795 MGI
is active in parallel fiber to Purkinje cell synapse IMP
IMP: Inferred from mutant phenotype
25556795 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
19671703 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily H member 1

EAG channel 1

ether a go-go

ether-a-go-go potassium channel 1

voltage-gated potassium channel subunit Kv10.1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07125 KCNH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnh1 NCBI NCBI:3756