Kcnj10 - potassium inwardly-rectifying channel, subfamily J, member 10 Gene

Also Known as BIR10; BIRK-1; Kir1.2; Kir4.1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16513

Summary

Enables inward rectifier Potassium Channel activity. Involved in non-motile cilium assembly. Acts upstream of or within several processes, including adult walking behavior; ion transmembrane transport; and regulation of resting membrane potential. Located in astrocyte projection; basolateral plasma membrane; and cell body. Is active in ciliary base. Is expressed in several structures, including brain; genitourinary system; spinal cord; stomach; and stria vascularis. Used to study EAST syndrome. Human ortholog(s) of this gene implicated in EAST syndrome and autosomal recessive nonsyndromic deafness 4. Orthologous to human KCNJ10 (potassium inwardly rectifying channel subfamily J member 10). [provided by Alliance of Genome Resources, Apr 2022]

Kcnj10 Products (1)

mRNA Protein Name
NM_001039484.1 NP_001034573.1 ATP-sensitive inward rectifier potassium channel 10

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables inward rectifier potassium channel activity IMP
IMP: Inferred from mutant phenotype
19515915 MGI
enables potassium channel activity IDA
IDA: Inferred from direct assay
9647694 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9647694 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adult walking behavior IMP
IMP: Inferred from mutant phenotype
10908613 MGI
involved in cellular response to potassium ion IMP
IMP: Inferred from mutant phenotype
31736353 MGI
acts upstream of or within central nervous system myelination IMP
IMP: Inferred from mutant phenotype
17942730 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
10908613 MGI
acts upstream of or within glutamate reuptake IMP
IMP: Inferred from mutant phenotype
17942730 MGI
involved in non-motile cilium assembly IMP
IMP: Inferred from mutant phenotype
26546361 MGI
acts upstream of or within oligodendrocyte development IMP
IMP: Inferred from mutant phenotype
17942730 MGI
acts upstream of or within potassium ion homeostasis IMP
IMP: Inferred from mutant phenotype
16306174 MGI
acts upstream of or within potassium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
10908613 MGI
acts upstream of or within potassium ion transport IDA
IDA: Inferred from direct assay
9647694 MGI
acts upstream of or within regulation of long-term neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
17942730 MGI
acts upstream of or within regulation of membrane potential IMP
IMP: Inferred from mutant phenotype
19515915 MGI
acts upstream of or within regulation of resting membrane potential IMP
IMP: Inferred from mutant phenotype
10908613 MGI
acts upstream of or within visual perception IMP
IMP: Inferred from mutant phenotype
10908613 MGI
Cellular Component GO Annotation Evidence References Source
located in astrocyte projection IDA
IDA: Inferred from direct assay
25716834 MGI
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
20651251 MGI
located in cell body IDA
IDA: Inferred from direct assay
25716834 MGI
is active in ciliary base IDA
IDA: Inferred from direct assay
26546361 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15310750 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-sensitive inward rectifier potassium channel 10

  • inward rectifier K(+) channel Kir4.1

  • potassium channel, inwardly rectifying subfamily J member 10

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07137 KCNJ10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnj10 NCBI NCBI:3766