Kcnj10 - potassium inwardly-rectifying channel, subfamily J, member 10 Gene

Mus musculus

Also known as BIR10; BIRK-1; Kir1.2; Kir4.1

Gene ID: 16513 | Gene type: protein coding

About Kcnj10

Summary

Enables inward rectifier Potassium Channel activity. Involved in non-motile cilium assembly. Acts upstream of or within several processes, including adult walking behavior; ion transmembrane transport; and regulation of resting membrane potential. Located in astrocyte projection; basolateral plasma membrane; and cell body. Is active in ciliary base. Is expressed in several structures, including brain; genitourinary system; spinal cord; stomach; and stria vascularis. Used to study EAST syndrome. Human ortholog(s) of this gene implicated in EAST syndrome and autosomal recessive nonsyndromic deafness 4. Orthologous to human KCNJ10 (potassium inwardly rectifying channel subfamily J member 10). [provided by Alliance of Genome Resources, Apr 2022]

Kcnj10 Products(1)

mRNA	Protein	Name
NM_001039484.1	NP_001034573.1	ATP-sensitive inward rectifier potassium channel 10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables inward rectifier potassium channel activity	IMP IMP: Inferred from mutant phenotype	19515915	MGI
enables potassium channel activity	IDA IDA: Inferred from direct assay	9647694	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9647694	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adult walking behavior	IMP IMP: Inferred from mutant phenotype	10908613	MGI
involved in cellular response to potassium ion	IMP IMP: Inferred from mutant phenotype	31736353	MGI
acts upstream of or within central nervous system myelination	IMP IMP: Inferred from mutant phenotype	17942730	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	10908613	MGI
acts upstream of or within glutamate reuptake	IMP IMP: Inferred from mutant phenotype	17942730	MGI
involved in non-motile cilium assembly	IMP IMP: Inferred from mutant phenotype	26546361	MGI
acts upstream of or within oligodendrocyte development	IMP IMP: Inferred from mutant phenotype	17942730	MGI
acts upstream of or within potassium ion homeostasis	IMP IMP: Inferred from mutant phenotype	16306174	MGI
acts upstream of or within potassium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	10908613	MGI
acts upstream of or within potassium ion transport	IDA IDA: Inferred from direct assay	9647694	MGI
acts upstream of or within regulation of long-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	17942730	MGI
acts upstream of or within regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	19515915	MGI
acts upstream of or within regulation of resting membrane potential	IMP IMP: Inferred from mutant phenotype	10908613	MGI
acts upstream of or within visual perception	IMP IMP: Inferred from mutant phenotype	10908613	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in astrocyte projection	IDA IDA: Inferred from direct assay	25716834	MGI
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	20651251	MGI
located in cell body	IDA IDA: Inferred from direct assay	25716834	MGI
is active in ciliary base	IDA IDA: Inferred from direct assay	26546361	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15310750	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ATP-sensitive inward rectifier potassium channel 10

inward rectifier K(+) channel Kir4.1

potassium channel, inwardly rectifying subfamily J member 10

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07137	KCNJ10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcnj10	NCBI	NCBI:3766

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