Kcnj6 - potassium inwardly-rectifying channel, subfamily J, member 6 Gene

Also Known as wv; BIR1; GIRK2; KATP2; KCNJ7; Kir3.2; weaver

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16522

Summary

Enables G-protein activated inward rectifier Potassium Channel activity. Acts upstream of or within thyroid hormone metabolic process. Located in parallel fiber to Purkinje cell synapse. Is integral component of presynaptic membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and skeleton. Human ortholog(s) of this gene implicated in alcohol use disorder and heroin dependence. Orthologous to human KCNJ6 (potassium inwardly rectifying channel subfamily J member 6). [provided by Alliance of Genome Resources, Apr 2022]

Kcnj6 Products (4)

mRNA Protein Name
NM_001025584.2 NP_001020755.1 G protein-activated inward rectifier potassium channel 2 isoform Girk2-1
NM_001025585.2 NP_001020756.1 G protein-activated inward rectifier potassium channel 2 isoform Girk2B
NM_001025590.2 NP_001020761.1 G protein-activated inward rectifier potassium channel 2 isoform Girk2C
NM_010606.2 NP_034736.2 G protein-activated inward rectifier potassium channel 2 isoform Girk2A-1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G-protein activated inward rectifier potassium channel activity IDA
IDA: Inferred from direct assay
7926018 MGI
enables potassium channel activity IDA
IDA: Inferred from direct assay
20393461 MGI
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
IDA: Inferred from direct assay
10956667 MGI
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
10956667 MGI
Cellular Component GO Annotation Evidence References Source
is active in parallel fiber to Purkinje cell synapse IDA
IDA: Inferred from direct assay
19558451 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
23804514 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
23804514 MGI
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
19558451 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

G protein-activated inward rectifier potassium channel 2

  • G-protein-coupled inward rectifier K+ channel 2-1

  • G-protein-coupled inward rectifier K+ channel 2-A

  • G-protein-coupled inward rectifier K+ channel 2-B

  • G-protein-coupled inward rectifier K+ channel 2-C

  • GIRK-2

  • inward rectifier K(+) channel Kir3.2

  • potas

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07149 KCNJ6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnj6 NCBI NCBI:3763