Kif5a - kinesin family member 5A Gene

Also Known as Khc; Kns; Kif5; mKIAA4086; D10Bwg0738e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16572

Summary

Enables Kinesin binding activity and microtubule binding activity. Involved in anterograde dendritic transport of neurotransmitter receptor complex and vesicle-mediated transport. Located in several cellular components, including ciliary rootlet; neuron projection; and neuronal cell body. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; hereditary spastic paraplegia 10; multiple sclerosis; prostate cancer; and rheumatoid arthritis. Orthologous to human KIF5A (Kinesin family member 5A). [provided by Alliance of Genome Resources, Apr 2022]

Kif5a Products (2)

mRNA Protein Name
NM_001039000.4 NP_001034089.1 kinesin heavy chain isoform 5A
NM_008447.4 NP_032473.2 kinesin heavy chain isoform 5A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables kinesin binding IPI
IPI: Inferred from physical interaction
18539120 MGI
enables microtubule binding IDA
IDA: Inferred from direct assay
17360631 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10964943 MGI
Biological Process GO Annotation Evidence References Source
involved in anterograde dendritic transport of neurotransmitter receptor complex IDA
IDA: Inferred from direct assay
11986669 MGI
involved in anterograde dendritic transport of neurotransmitter receptor complex IMP
IMP: Inferred from mutant phenotype
11986669 MGI
involved in vesicle-mediated transport IDA
IDA: Inferred from direct assay
21976701 MGI
Cellular Component GO Annotation Evidence References Source
located in ciliary rootlet IDA
IDA: Inferred from direct assay
16018997 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
16018997 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
16301330 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
17360631 MGI
is active in postsynaptic cytosol IDA
IDA: Inferred from direct assay
31961321 MGI
is active in postsynaptic cytosol IEP
IEP: Inferred from expression pattern
31961321 MGI
is active in postsynaptic cytosol IMP
IMP: Inferred from mutant phenotype
31961321 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kinesin heavy chain isoform 5A

kinesin heavy chain

  • NKHC

  • kinesin heavy chain neuron-specific 1

  • neuronal kinesin heavy chain

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07289 KIF5A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kif5a NCBI NCBI:3798