Kpna6 - karyopherin (importin) alpha 6 Gene

Mus musculus

Also known as IPOA7; Kpna5; NPI-2

Gene ID: 16650 | Gene type: protein coding

About Kpna6

Summary

Enables nuclear import signal receptor activity. Acts upstream of or within several processes, including entry of viral genome into host nucleus through nuclear pore complex via importin; positive regulation of macromolecule metabolic process; and protein import into nucleus. Predicted to be located in cytoplasm. Predicted to be active in nucleoplasm. Is expressed in several structures, including heart; liver; lung; oocyte; and spleen. Orthologous to human KPNA6 (karyopherin subunit alpha 6). [provided by Alliance of Genome Resources, Apr 2022]

Kpna6 Products(1)

mRNA	Protein	Name
NM_008468.4	NP_032494.3	importin subunit alpha-7

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables nuclear import signal receptor activity	IDA IDA: Inferred from direct assay	15689618	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15689618	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within entry of viral genome into host nucleus through nuclear pore complex via importin	IMP IMP: Inferred from mutant phenotype	28189564	MGI
acts upstream of or within maternal process involved in female pregnancy	IMP IMP: Inferred from mutant phenotype	21479251	MGI
acts upstream of or within positive regulation of cytokine production involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	28189564	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21479251	MGI
acts upstream of or within positive regulation of viral life cycle	IMP IMP: Inferred from mutant phenotype	28189564	MGI
acts upstream of or within protein import into nucleus	IDA IDA: Inferred from direct assay	15689618	MGI
acts upstream of or within symbiont-mediated perturbation of host defenses	IMP IMP: Inferred from mutant phenotype	28189564	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21479251	MGI
acts upstream of or within viral genome replication	IMP IMP: Inferred from mutant phenotype	28189564	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

importin subunit alpha-7

importin alpha 7	importin alpha-S2
karyopherin (importin) alpha 5	karyopherin subunit alpha-6

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07420	KPNA6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kpna6	NCBI	NCBI:23633

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