Kpna6 - karyopherin (importin) alpha 6 Gene

Also Known as IPOA7; Kpna5; NPI-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16650

Summary

Enables nuclear import signal receptor activity. Acts upstream of or within several processes, including entry of viral genome into host nucleus through nuclear pore complex via importin; positive regulation of macromolecule metabolic process; and protein import into nucleus. Predicted to be located in cytoplasm. Predicted to be active in nucleoplasm. Is expressed in several structures, including heart; liver; lung; oocyte; and spleen. Orthologous to human KPNA6 (karyopherin subunit alpha 6). [provided by Alliance of Genome Resources, Apr 2022]

Kpna6 Products (1)

mRNA Protein Name
NM_008468.4 NP_032494.3 importin subunit alpha-7

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables nuclear import signal receptor activity IDA
IDA: Inferred from direct assay
15689618 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15689618 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within entry of viral genome into host nucleus through nuclear pore complex via importin IMP
IMP: Inferred from mutant phenotype
28189564 MGI
acts upstream of or within maternal process involved in female pregnancy IMP
IMP: Inferred from mutant phenotype
21479251 MGI
acts upstream of or within positive regulation of cytokine production involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
28189564 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21479251 MGI
acts upstream of or within positive regulation of viral life cycle IMP
IMP: Inferred from mutant phenotype
28189564 MGI
acts upstream of or within protein import into nucleus IDA
IDA: Inferred from direct assay
15689618 MGI
acts upstream of or within symbiont-mediated perturbation of host defenses IMP
IMP: Inferred from mutant phenotype
28189564 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21479251 MGI
acts upstream of or within viral genome replication IMP
IMP: Inferred from mutant phenotype
28189564 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

importin subunit alpha-7

  • importin alpha 7

  • importin alpha-S2

  • karyopherin (importin) alpha 5

  • karyopherin subunit alpha-6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07420 KPNA6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kpna6 NCBI NCBI:23633