Lama4 - laminin, alpha 4 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16775

Summary

Predicted to enable signaling receptor binding activity. Predicted to be an extracellular matrix structural constituent. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within blood vessel development and brown fat cell differentiation. Located in basement membrane and neuromuscular junction. Is active in synaptic cleft. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1JJ. Orthologous to human LAMA4 (laminin subunit alpha 4). [provided by Alliance of Genome Resources, Apr 2022]

Lama4 Products (1)

mRNA Protein Name
NM_010681.4 NP_034811.2 laminin subunit alpha-4 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within blood vessel development IMP
IMP: Inferred from mutant phenotype
11809810 MGI
acts upstream of or within brown fat cell differentiation IDA
IDA: Inferred from direct assay
18492766 MGI
involved in negative regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
28973559 MGI
Cellular Component GO Annotation Evidence References Source
located in basement membrane IDA
IDA: Inferred from direct assay
9346933 MGI
is active in neuromuscular junction IDA
IDA: Inferred from direct assay
9396756 MGI
is active in synaptic cleft IDA
IDA: Inferred from direct assay
9396756 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

laminin subunit alpha-4

  • laminin [a]4

  • laminin-14 subunit alpha

  • laminin-8 subunit alpha

  • laminin-9 subunit alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07500 LAMA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21622 Lama4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28140 Lama4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lama4 NCBI NCBI:3910